Highly expressed IFITM10 is associated with early diagnosis and T stage of gastric cancer.
Highly expressed IFITM10 is associated with early diagnosis and T stage of gastric cancer.
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高表达 IFITM10 与胃癌早期诊断及 T 分期相关
DOI：
10.21037/tcr-20-2333
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发表时间：
2021-01
影响因子：
0.9
通讯作者：
Zhu J
中科院分区：
文献类型：
--
作者：
Liu Y;Liu J;Tian Z;Zhang Z;Liu T;Chen C;Tang X;Zhu J
干扰素诱导跨膜蛋白（IFITMs）是一类功能主要包括控制细胞增殖、促进同型细胞粘附和预防病毒感染的蛋白。本研究旨在阐明IFITM10表达水平与胃癌（GC）的关系。方法从癌症基因组图谱（Cancer Genome Atlas， TCGA）数据库中获取胃癌和正常组织的转录组测序和临床信息。基于现有临床资料，采用R及相关统计软件包分析IFITM10与胃癌患者生存的关系。采用SPSS软件包构建受试者工作特征曲线（ROC）。采用qPCR检测患者组织样本中IFITM10的表达水平，并使用SPSS分析IFITM10表达与临床特征的相关性。使用基因集富集分析（GSEA）分析IFITM10相关的信号通路。结果在TCGA数据库中，IFITM10在GC组织中高表达（P<0.001）。IFITM10在所有样品中的曲线下面积（Area under the curve， AUC）值为0.813，在配对的GC及邻近组织中的AUC值为0.955。在手术患者样本中，IFITM10在GC组织中高表达（P<0.001）。IFITM10在T1和T2组织（P=0.042）、男性患者（P=0.031）和无神经浸润组织（P=0.008）中表达较高。结论IFITM10在胃癌中高表达，可作为胃癌早期诊断指标。IFITM10的高表达与GC低T期有关。
Background Interferon-induced transmembrane proteins (IFITMs) are a family of proteins which functions mainly include controlling cell proliferation, promoting homotypic cell adhesion, and preventing viral infection. This research study attempts to elucidate the association between IFITM10 expression level and gastric cancer (GC). Methods Transcriptome sequencing and clinical information on GC and normal tissues was obtained from the Cancer Genome Atlas (TCGA) database. R and related statistical packages were used to analyze the relationship between IFITM10 and survival in GC patients based on available clinical information. Receiver operating characteristic curves (ROC) were constructed using the SPSS software package. IFITM10 expression levels in patients tissue samples were examined by qPCR and association between IFITM10 expression and clinic characteristics was analyzed using SPSS. The signaling pathway associated with IFITM10 was analyzed using gene set enrichment analysis (GSEA). Results In the TCGA database, IFITM10 was highly expressed in GC tissues (P<0.001). Area under the curve (AUC) value for IFITM10 in all samples was 0.813, while AUC value in the paired GC and adjacent tissues was 0.955. In the sample of surgical patients, IFITM10 was highly expressed in GC tissues (P<0.001). IFITM10 expression was higher in T1 and T2 tissues (P=0.042), male patients (P=0.031), and tissues without neuro infiltration (P=0.008). Conclusions IFITM10 is highly expressed in GC and can serve as an early diagnostic indicator. High expression of IFITM10 was related to a low T stage in GC.
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影响因子：
11.1
作者：
Borg D;Hedner C;Gaber A;Nodin B;Fristedt R;Jirström K;Eberhard J;Johnsson A
通讯作者：
Johnsson A
影响因子：
3.3
作者：
Kamath, Suneel D.;Kalyan, Aparna;Benson, Al B., III
通讯作者：
Benson, Al B., III
IGF1/IGF1R/STAT3信号诱导的IFITM2促进胃癌生长和转移
影响因子：
9.7
作者：
Xu, Li;Zhou, Rui;Liao, Wangjun
通讯作者：
Liao, Wangjun
影响因子：
2.9
作者：
Jia Y;Xiao Z;Jiang W;Chen G;Wang Z
通讯作者：
Wang Z
影响因子：
4.2
作者：
Hu, Jun;Wang, Shuwei;Sun, Yueming
通讯作者：
Sun, Yueming