Gut Microbiota in Tibetan Herdsmen Reflects the Degree of Urbanization.
Gut Microbiota in Tibetan Herdsmen Reflects the Degree of Urbanization.
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西藏牧民肠道菌群反映城市化程度
DOI：
10.3389/fmicb.2018.01745
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发表时间：
2018
影响因子：
5.2
通讯作者：
Qu J
中科院分区：
文献类型：
--
作者：
Li H;Li T;Li X;Wang G;Lin Q;Qu J
城市化与人类生活方式的转变有关，因此可能影响肠道微生物区系的多样性、相互作用和组装。然而，关于人类肠道微生物区系如何适应不同的生活方式的问题仍然难以捉摸。为了了解肠道微生物区系与城市化的关系，我们比较了传统牧民(TH)、半城镇化牧民(SuH)和城市牧民(UH)三个不同城市化水平地区牧民肠道微生物群落的多样性、互动性和聚集性。普氏杆菌的相对丰度随城市化程度的增加而降低(从TH到UH)，类杆菌、粪便杆菌和蓝藻的相对丰度则呈现相反的趋势。虽然肠道微生物区系的α多样性指标(观测到的OTUS和系统发育多样性)不受城市化的影响，但β多样性(Jaccard距离或Bray-Curtis距离)受到城市化的显著影响。元基因组预测显示，与代谢相关的基因功能(即碳水化合物和脂肪代谢)在TH和UH之间存在显著差异。网络分析表明，模块化程度随着城市化程度的提高而增加，表明城市生态位分化程度较高。同时，网络密度的变化趋势与之相反，显示出更复杂的网络。值得注意的是，控制群落集合的环境过滤的相对重要性随着城市化程度的增加而增加，这表明确定性因素(例如低纤维饮食)在塑造肠道微生物区系方面发挥着比随机因素(例如随机分散)更重要的作用。对生态过程的量化表明，UH比TH具有更强的变量选择信号，这意味着不同的选择压力导致城市生活方式导致肠道群落组成的差异。我们的结果表明，肠道微生物区系的β多样性、网络相互作用和生态过程可能反映了城市化的程度，并突出了人类肠道微生物区系对生活方式变化的适应。
Urbanization is associated with shifts in human lifestyles, thus possibly influencing the diversity, interaction and assembly of gut microbiota. However, the question regarding how human gut microbiota adapts to varying lifestyles remains elusive. To understand the relationship between gut microbiota and urbanization, we compared the diversity, interaction and assembly of gut microbial communities of herdsmen from three regions with different levels of urbanization, namely traditional herdsmen (TH), semi-urban herdsmen (SUH) and urban herdsmen (UH). The relative abundance of Prevotella decreased with the degree of urbanization (from TH to UH), whereas that of Bacteroides, Faecalibacterium, and Blautia showed an opposite trend. Although the alpha diversity measures (observed OTUs and phylogenetic diversity) of gut microbiota were unaffected by urbanization, the beta diversity (Jaccard or Bray–Curtis distances) was significantly influenced by urbanization. Metagenome prediction revealed that the gene functions associated with metabolism (i.e., carbohydrate and lipid metabolism) had significant differences between TH and UH. Network analysis showed that the modularity increased with the degree of urbanization, indicating a high extent of niche differentiation in UH. Meanwhile the trend of network density was opposite, indicating a more complex network in TH. Notably, the relative importance of environmental filtering that governed the community assembly increased with the degree of urbanization, which indicated that deterministic factors (e.g., low-fiber diet) play more important roles than stochastic factors (e.g., stochastic dispersal) in shaping the gut microbiota. A quantification of ecological processes showed a stronger signal of variable selection in UH than TH, implying that different selective pressures cause divergent gut community compositions due to urban lifestyles. Our results suggest that beta diversity, network interactions and ecological processes of gut microbiota may reflect the degree of urbanization, and highlight the adaptation of human gut microbiota to lifestyle changes.
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鼠兔种群密度与肠道微生物群的组成和多样性有关
影响因子：
5.2
作者：
Li H;Qu J;Li T;Li J;Lin Q;Li X
通讯作者：
Li X
DOI：
10.1126/science.1224203
发表时间：
2012-06-08
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Costello EK;Stagaman K;Dethlefsen L;Bohannan BJ;Relman DA
通讯作者：
Relman DA
DOI：
10.1111/j.1365-2656.2010.01738.x
发表时间：
2010-11
期刊：
The Journal of animal ecology
影响因子：
--
作者：
Purves DW;Turnbull LA
通讯作者：
Turnbull LA
影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
5.8
作者：
Kembel, Steven W.;Cowan, Peter D.;Webb, Campbell O.
通讯作者：
Webb, Campbell O.