S-Glutathionylation-Controlled Apoptosis of Lung Epithelial Cells; Potential Implications for Lung Fibrosis.
S-Glutathionylation-Controlled Apoptosis of Lung Epithelial Cells; Potential Implications for Lung Fibrosis.
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s -谷胱甘肽调控肺上皮细胞凋亡肺纤维化的潜在意义。
DOI：
10.3390/antiox11091789
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发表时间：
2022-09-10
期刊：
影响因子：
7
通讯作者：
Janssen-Heininger, Yvonne
中科院分区：
文献类型：
--
作者：
Corteselli, Elizabeth;Aboushousha, Reem;Janssen-Heininger, Yvonne
谷胱甘肽（GSH）是哺乳动物细胞中的主要抗氧化剂，调节几个重要的细胞过程，如营养代谢，蛋白质合成和免疫反应。除了其在抗氧化防御中的作用之外，GSH还通过其在被称为蛋白S-谷胱甘肽化（PSSG）的翻译后修饰中与反应性蛋白半胱氨酸缀合来控制生物过程。PSSG最近被认为与包括特发性肺纤维化（IPF）在内的多种疾病的发病机制有关。IPF的特征包括肺泡上皮反复损伤伴异常组织修复、上皮细胞凋亡和成纤维细胞对凋亡的抵抗、细胞外基质蓄积和正常肺结构的扭曲。几项研究将氧化应激和PSSG与IPF的发生和进展联系起来。此外，已经表明上皮细胞稳态的丧失和细胞凋亡的增加，伴随着各种代谢物的释放，产生了加速疾病进展的恶性循环。在这篇简短的综述中，我们重点介绍了最近的一些研究，PSSG上皮细胞凋亡，并强调了潜在的影响，由凋亡细胞分泌的代谢产物。
Glutathione (GSH), a major antioxidant in mammalian cells, regulates several vital cellular processes, such as nutrient metabolism, protein synthesis, and immune responses. In addition to its role in antioxidant defense, GSH controls biological processes through its conjugation to reactive protein cysteines in a post-translational modification known as protein S-glutathionylation (PSSG). PSSG has recently been implicated in the pathogenesis of multiple diseases including idiopathic pulmonary fibrosis (IPF). Hallmarks of IPF include repeated injury to the alveolar epithelium with aberrant tissue repair, epithelial cell apoptosis and fibroblast resistance to apoptosis, and the accumulation of extracellular matrix and distortion of normal lung architecture. Several studies have linked oxidative stress and PSSG to the development and progression of IPF. Additionally, it has been suggested that the loss of epithelial cell homeostasis and increased apoptosis, accompanied by the release of various metabolites, creates a vicious cycle that aggravates disease progression. In this short review, we highlight some recent studies that link PSSG to epithelial cell apoptosis and highlight the potential implication of metabolites secreted by apoptotic cells.
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谷胱甘肽1控制营养应激过程中的单核细胞重编程，并以性别特异性的方式保护小鼠免受肥胖和动脉粥样硬化的侵害。
影响因子：
16.6
作者：
Ahn YJ;Wang L;Tavakoli S;Nguyen HN;Short JD;Asmis R
通讯作者：
Asmis R
影响因子：
24.3
作者：
Beeh, KM;Beier, J;Buhl, R
通讯作者：
Buhl, R
影响因子：
10.6
作者：
Forman, Henry Jay;Zhang, Hongqiao;Rinna, Alessandra
通讯作者：
Rinna, Alessandra
DOI：
10.1164/ajrccm.159.6.9810044
发表时间：
1999-06-01
影响因子：
24.7
作者：
Comhair, SAA;Lewis, MJ;Erzurum, SC
通讯作者：
Erzurum, SC
影响因子：
4.4
作者：
Armstrong, JS;Whiteman, M;Sternberg, P
通讯作者：
Sternberg, P