Risk of incident sleep disorders in patients with prurigo nodularis: A population-level analysis using The Health Improvement Network.
Risk of incident sleep disorders in patients with prurigo nodularis: A population-level analysis using The Health Improvement Network.
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DOI：
10.1016/j.jdin.2023.07.009
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发表时间：
2023-12
影响因子：
--
通讯作者：
Kwatra, Shawn G.
中科院分区：
文献类型：
--
作者：
Joel, Marina Z.;Taylor, Matthew T.;Cornman, Hannah L.;Kambala, Anusha;Reddy, Sriya V.;Gabriel, Sylvie;Kwatra, Shawn G.
结节性痒疹(PN)是一种慢性炎症性皮肤疾病，其特征是手臂、腿和躯干上出现严重瘙痒和疼痛的肿块。目前尚不清楚PN患者是否会增加发展为睡眠障碍的风险。目的：探讨PN与睡眠障碍的关系。这项回溯性、人群水平的匹配队列研究是利用健康改善网络进行的。这项研究包括4193名新诊断的PN患者和4193名年龄、性别和种族/民族匹配的对照组。使用COX回归模型评估PN患者与对照组相比睡眠障碍的发展，包括失眠、睡眠呼吸暂停和不宁腿综合征。与对照组相比，PN与失眠(调整后的危险比[AHR]=11.77；95%CI=11.48-2.12)和整体睡眠障碍(AHR=61.72；95%CI=91.46-2.02)有关，但与睡眠呼吸暂停(AHR=91.51；95%CI=90.93-2.44)或不宁腿综合征(AHR=11.54；95%CI=60.92-2.57)无关。作为一项回溯性队列研究，我们的分析受到尚未纳入的潜在混杂因素的影响。PN与随后的失眠相关。因此，临床医生应该考虑PN患者的失眠情况，并制定治疗和预防策略。
Prurigo nodularis (PN) is a chronic inflammatory skin condition characterized by severely itchy and often painful bumps on the arms, legs, and trunk. It is unknown whether patients with PN have increased risk of developing sleep disorders. To evaluate the association of PN with sleep disorders. This retrospective, population-level, matched-cohort study was conducted using The Health Improvement Network. The study included 4193 patients with newly diagnosed PN and 4193 age, sex, and race/ethnicity-matched controls. A Cox regression model was used to assess the development of sleep disorders, including insomnia, sleep apnea, and restless legs syndrome, in patients with PN compared with control patients. Compared with controls, PN was associated with insomnia (adjusted hazard ratio [aHR] = 1.77; 95% CI = 1.48-2.12) and overall sleep disorder (aHR = 1.72; 95% CI = 1.46-2.02), but not with sleep apnea (aHR = 1.51; 95% CI = 0.93-2.44) or restless legs syndrome (aHR = 1.54; 95% CI = 0.92-2.57). As a retrospective cohort study, our analysis is subject to potential confounders not already included. PN was associated with subsequent development of insomnia. Thus, clinicians should consider insomnia among patients with PN and develop strategies for treatment and prevention.
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影响因子：
13.8
作者：
Bender, Alexandra M.;Tang, Olive;Kwatra, Shawn G.
通讯作者：
Kwatra, Shawn G.
影响因子：
13.8
作者：
Chiricozzi, Andrea;Maurelli, Martina;Peris, Ketty
通讯作者：
Peris, Ketty
DOI：
10.1111/jdv.14570
发表时间：
2018-07-01
影响因子：
9.2
作者：
Pereira, M. P.;Steinke, S.;Staender, S.
通讯作者：
Staender, S.
影响因子：
158.5
作者：
Staender, Sonja;Yosipovitch, Gil;Piketty, Christophe
通讯作者：
Piketty, Christophe
影响因子：
6.7
作者：
Fernandez-Mendoza, Julio;Vgontzas, Alexandros N.
通讯作者：
Vgontzas, Alexandros N.