Effects of intranasal oxytocin and vasopressin on cooperative behavior and associated brain activity in men.
Effects of intranasal oxytocin and vasopressin on cooperative behavior and associated brain activity in men.
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DOI：
10.1016/j.psyneuen.2011.07.013
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发表时间：
2012-04
影响因子：
3.7
通讯作者：
Pagnoni, Giuseppe
中科院分区：
文献类型：
--
作者：
Rilling, James K.;DeMarco, Ashley C.;Hackett, Patrick D.;Thompson, Richmond;Ditzen, Beate;Patel, Rajan;Pagnoni, Giuseppe
支持成年男性之间社会联系的神经机制仍然不确定。在这项双盲，安慰剂对照研究中，我们调查了鼻内注射催产素（OT）和加压素（AVP）对男性行为和大脑活动的影响，在重复的囚徒困境游戏的背景下，模拟现实生活中的社会情况。功能磁共振成像结果表明，相对于AVP和安慰剂，OT增加尾状核反应的互惠合作，这可能会增加回报的互惠合作和/或促进学习，另一个人可以信任。OT还增强了左杏仁核的激活，以响应互惠合作。在行为上，OT与合作率增加后，在上一轮的互惠合作相比，AVP。与安慰剂和OT相比，AVP强烈增加了合作伙伴对合作姿态的反应。在回应互惠合作，AVP增加激活的区域跨越已知的加压素电路牵连在其他物种的亲和行为。最后，相对于安慰剂，OT和AVP都增加了杏仁核与前额叶的功能连接，这可能会增加杏仁核引出指导决策的内脏躯体标记的能力。这些发现将我们对OT和AVP的神经和行为影响的认识扩展到了真正的社会互动背景下。
The neural mechanisms supporting social bonds between adult men remain uncertain. In this double-blind, placebo-controlled study, we investigate the impact of intranasally administered oxytocin (OT) and vasopressin (AVP) on behavior and brain activity among men in the context of an iterated Prisoner’s Dilemma game, which models a real-life social situation. fMRI results show that, relative to both AVP and placebo, OT increases the caudate nucleus response to reciprocated cooperation, which may augment the reward of reciprocated cooperation and/or facilitate learning that another person can be trusted. OT also enhances left amygdala activation in response to reciprocated cooperation. Behaviorally, OT was associated with increased rates of cooperation following unreciprocated cooperation in the previous round compared with AVP. AVP strongly increased cooperation in response to a cooperative gesture by the partner compared with both placebo and OT. In response to reciprocated cooperation, AVP increased activation in a region spanning known vasopressin circuitry implicated in affiliative behaviors in other species. Finally, both OT and AVP increase amygdala functional connectivity with the anterior insula relative to placebo, which may increase the amygdala’s ability to elicit visceral somatic markers that guide decision making. These findings extend our knowledge of the neural and behavioral effects of OT and AVP to the context of genuine social interactions.
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影响因子：
16.2
作者：
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