GOLD.db: genomics of lipid-associated disorders database.
GOLD.db: genomics of lipid-associated disorders database.
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DOI：
10.1186/1471-2164-5-93
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发表时间：
2004-12-10
期刊：
影响因子：
4.4
通讯作者：
Trajanoski Z
中科院分区：
文献类型：
--
作者：
Hackl H;Maurer M;Mlecnik B;Hartler J;Stocker G;Miranda-Saavedra D;Trajanoski Z
GOLD.db（脂质相关疾病基因组学数据库）的开发是为了满足整合与脂质相关疾病的生物学、诊断管理、治疗和预防特别相关的基因及其产物的功能和特性的不同信息的需求。GOLD.db以有效组织的方式提供了有关相关基因和蛋白质的途径和信息的参考。其主要目的是为脂质代谢和肥胖相关研究提供生物学途径的图像地图和视觉途径信息。该数据库还提供了将基因表达数据单独映射到每个途径的可能性。不同实验条件下的基因表达可以在途径的背景下顺序观察。提供了相关的大规模基因表达数据集，并且可以搜索特定基因以整合关于其在不同研究和条件下的表达水平的信息。分析和数据挖掘工具、试剂、方案、参考文献和相关基因组资源的链接都包括在数据库中。最后，以脂肪细胞分化过程中Pten mRNA的调控为例，验证了数据库的可用性。GOLD.db将是一个有价值的工具，使研究人员能够有效地分析基因表达的模式，并以各种有用和信息丰富的方式显示它们，允许外部研究人员在生物过程和途径的背景下进行与基因表达结果有关的查询。
The GOLD.db (Genomics of Lipid-Associated Disorders Database) was developed to address the need for integrating disparate information on the function and properties of genes and their products that are particularly relevant to the biology, diagnosis management, treatment, and prevention of lipid-associated disorders. The GOLD.db provides a reference for pathways and information about the relevant genes and proteins in an efficiently organized way. The main focus was to provide biological pathways with image maps and visual pathway information for lipid metabolism and obesity-related research. This database provides also the possibility to map gene expression data individually to each pathway. Gene expression at different experimental conditions can be viewed sequentially in context of the pathway. Related large scale gene expression data sets were provided and can be searched for specific genes to integrate information regarding their expression levels in different studies and conditions. Analytic and data mining tools, reagents, protocols, references, and links to relevant genomic resources were included in the database. Finally, the usability of the database was demonstrated using an example about the regulation of Pten mRNA during adipocyte differentiation in the context of relevant pathways. The GOLD.db will be a valuable tool that allow researchers to efficiently analyze patterns of gene expression and to display them in a variety of useful and informative ways, allowing outside researchers to perform queries pertaining to gene expression results in the context of biological processes and pathways.
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影响因子：
4.8
作者：
Hansen, JB;Petersen, RK;Kristiansen, K
通讯作者：
Kristiansen, K
影响因子：
10.5
作者：
Chen, PL;Riley, DJ;Lee, WH
通讯作者：
Lee, WH
DOI：
10.1073/pnas.85.8.2444
发表时间：
1988-04-01
影响因子：
11.1
作者：
PEARSON, WR;LIPMAN, DJ
通讯作者：
LIPMAN, DJ
影响因子：
5.8
作者：
Trost, E;Hackl, H;Trajanoski, Z
通讯作者：
Trajanoski, Z
影响因子：
4.9
作者：
Flegal, KM;Carroll, MD;Johnson, CL
通讯作者：
Johnson, CL