Vaccination increased host antiviral gene expression and reduced COVID-19 severity during the Omicron variant outbreak in Fuyang City, China.
Vaccination increased host antiviral gene expression and reduced COVID-19 severity during the Omicron variant outbreak in Fuyang City, China.
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DOI：
10.1016/j.intimp.2023.110333
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发表时间：
2023-07
影响因子：
5.6
通讯作者：
Lin, Wenyu
中科院分区：
文献类型：
--
作者：
Li, Shasha;Duan, Xiaoqiong;Jiang, Ning;Jeyarajan, Andre J.;Warner, Charlotte A.;Li, Yujia;Xu, Min;Li, Xiuyong;Tan, Lin;Li, Ming;Shao, Tuo;Li, Shilin;Chen, Limin;Gao, Yufeng;Han, Mingfeng;Lin, Wenyu
接种疫苗和未接种疫苗的2019冠状病毒病（COVID-19）患者之间宿主抗病毒基因表达和疾病严重程度的差异尚未得到很好的表征。我们试图比较阜阳市第二人民医院接种疫苗和未接种疫苗队列的临床特征和宿主抗病毒基因表达模式。在这项病例对照研究中，我们回顾性分析了从阜阳市第二人民医院招募的113名接种疫苗的COVID-19 Omicron变异体感染患者，46名未接种疫苗的COVID-19患者和24名健康受试者（无COVID-19病史）。从每名研究参与者中采集血液样品用于RNA提取和PCR。我们比较了健康对照和感染时接种或未接种疫苗的COVID-19患者之间的宿主抗病毒基因表达谱。在接种疫苗组中，大多数患者无症状，仅有42. 9%的患者出现发热。值得注意的是，没有患者发生肺外器官损伤。相比之下，未接种疫苗组中21.4%的患者发生重度/危重（SC）疾病，78.6%的患者发生轻度/中度（MM）疾病，74.2%的患者发生发热。我们发现，接种COVID-19疫苗的患者中Omicron感染与几种重要宿主抗病毒基因的表达显著增加相关，包括IL 12 B、IL 13、CXCL 11、CXCL 9、IFNA 2、IFNA 1、IFNγ和TNFα。感染Omicron变异体的疫苗接种患者大多无症状。相比之下，未接种疫苗的患者经常发生SC或MM疾病。患有SC COVID-19的老年患者轻度肝功能障碍的发生率也较高。接种COVID-19疫苗的患者中的Omicron感染与关键宿主抗病毒基因的激活有关，因此可能在降低疾病严重程度方面发挥作用。
The differences in host antiviral gene expression and disease severity between vaccinated and non-vaccinated coronavirus disease 2019 (COVID-19) patients are not well characterized. We sought to compare the clinical characteristics and host antiviral gene expression patterns of vaccinated and non-vaccinated cohorts at the Second People's Hospital of Fuyang City. In this case-control study, we retrospectively analyzed 113 vaccinated patients with a COVID-19 Omicron variant infection, 46 non-vaccinated COVID-19 patients, and 24 healthy subjects (no history of COVID-19) recruited from the Second People's Hospital of Fuyang City. Blood samples were collected from each study participant for RNA extraction and PCR. We compared host antiviral gene expression profiles between healthy controls and COVID-19 patients who were either vaccinated or non-vaccinated at the time of infection. In the vaccinated group, most patients were asymptomatic, with only 42.9 % of patients developing fever. Notably, no patients had extrapulmonary organ damage. In contrast, 21.4 % of patients in the non-vaccinated group developed severe/critical (SC) disease and 78.6 % had mild/moderate (MM) disease, with fever occurring in 74.2 % patients. We found that Omicron infection in COVID-19 vaccinated patients was associated with significantly increased expression of several important host antiviral genes including IL12B, IL13, CXCL11, CXCL9, IFNA2, IFNA1, IFNγ, and TNFα. Vaccinated patients infected with the Omicron variant were mostly asymptomatic. In contrast, non-vaccinated patients frequently developed SC or MM disease. Older patients with SC COVID-19 also had a higher occurrence of mild liver dysfunction. Omicron infection in COVID-19 vaccinated patients was associated with the activation of key host antiviral genes and thus may play a role in reducing disease severity.
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影响因子：
5
作者：
Gadotti AC;de Castro Deus M;Telles JP;Wind R;Goes M;Garcia Charello Ossoski R;de Padua AM;de Noronha L;Moreno-Amaral A;Baena CP;Tuon FF
通讯作者：
Tuon FF
DOI：
10.3390/v13061062
发表时间：
2021-06-03
期刊：
Viruses
影响因子：
--
作者：
Callahan V;Hawks S;Crawford MA;Lehman CW;Morrison HA;Ivester HM;Akhrymuk I;Boghdeh N;Flor R;Finkielstein CV;Allen IC;Weger-Lucarelli J;Duggal N;Hughes MA;Kehn-Hall K
通讯作者：
Kehn-Hall K
影响因子：
7.3
作者：
Alivernini S;Gremese E;McSharry C;Tolusso B;Ferraccioli G;McInnes IB;Kurowska-Stolarska M
通讯作者：
Kurowska-Stolarska M
影响因子：
8
作者：
Donlan AN;Sutherland TE;Marie C;Preissner S;Bradley BT;Carpenter RM;Sturek JM;Ma JZ;Moreau GB;Donowitz JR;Buck GA;Serrano MG;Burgess SL;Abhyankar MM;Mura C;Bourne PE;Preissner R;Young MK;Lyons GR;Loomba JJ;Ratcliffe SJ;Poulter MD;Mathers AJ;Day AJ;Mann BJ;Allen JE;Petri WA Jr
通讯作者：
Petri WA Jr
影响因子：
15.9
作者：
Gong, Fang;Dai, Yaping;Zhou, Pengcheng
通讯作者：
Zhou, Pengcheng