Initiation of the adaptive immune response to Mycobacterium tuberculosis depends on antigen production in the local lymph node, not the lungs.
Initiation of the adaptive immune response to Mycobacterium tuberculosis depends on antigen production in the local lymph node, not the lungs.
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DOI：
10.1084/jem.20071367
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发表时间：
2008-01-21
期刊：
影响因子：
--
通讯作者：
Ernst JD
中科院分区：
文献类型：
--
作者：
Wolf AJ;Desvignes L;Linas B;Banaiee N;Tamura T;Takatsu K;Ernst JD
与其他感染或免疫相比，对结核分枝杆菌的适应性免疫反应的发生延迟，并使肺部的细菌种群在感染的免疫前阶段显着扩大。我们使用结核分枝杆菌ag85b特异性CD4+ T细胞的过继转移来确定延迟的适应性反应是由CD4+ T细胞初始激活的延迟引起的，这最早发生在局部肺排纵隔淋巴结。我们还发现，ag85b特异性T细胞的初始激活依赖于淋巴结中细菌产生抗原，尽管肺部存在100倍以上的细菌。虽然已经发现树突状细胞可以将结核分枝杆菌从肺部转运到局部淋巴结，但气道给药LPS并不会加速细菌转运到淋巴结，也不会加速ag85b特异性T细胞的活化。这些结果表明，结核中CD4+ T细胞的延迟初始激活是由于细菌存在于不能从肺部动员到淋巴结（初始T细胞激活发生的地方）的隔室中引起的。
The onset of the adaptive immune response to Mycobacterium tuberculosis is delayed compared with that of other infections or immunization, and allows the bacterial population in the lungs to expand markedly during the preimmune phase of infection. We used adoptive transfer of M. tuberculosis Ag85B-specific CD4+ T cells to determine that the delayed adaptive response is caused by a delay in initial activation of CD4+ T cells, which occurs earliest in the local lung-draining mediastinal lymph node. We also found that initial activation of Ag85B-specific T cells depends on production of antigen by bacteria in the lymph node, despite the presence of 100-fold more bacteria in the lungs. Although dendritic cells have been found to transport M. tuberculosis from the lungs to the local lymph node, airway administration of LPS did not accelerate transport of bacteria to the lymph node and did not accelerate activation of Ag85B-specific T cells. These results indicate that delayed initial activation of CD4+ T cells in tuberculosis is caused by the presence of the bacteria in a compartment that cannot be mobilized from the lungs to the lymph node, where initial T cell activation occurs.
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