Both a nicotinic single nucleotide polymorphism (SNP) and a noradrenergic SNP modulate working memory performance when attention is manipulated.
Both a nicotinic single nucleotide polymorphism (SNP) and a noradrenergic SNP modulate working memory performance when attention is manipulated.
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DOI：
10.1162/jocn.2008.21164
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发表时间：
2009-11
影响因子：
3.2
通讯作者：
Parasuraman R
中科院分区：
文献类型：
--
作者：
Greenwood PM;Sundararajan R;Lin MK;Kumar R;Fryxell KJ;Parasuraman R
我们通过研究胆碱能和去甲肾上腺素能基因的正常变异对注意操纵下工作记忆表现的影响，探讨了视觉空间注意和工作记忆两个系统之间的关系。我们以前曾报道过，位置的工作记忆受损后，大的位置precues，表明视觉空间注意的规模在形成的心理表征的目标有一定的作用。在比较两种单核苷酸多态性（SNP）对同一认知任务的影响的首批研究中，我们研究了注意力和记忆之间相互作用的神经传递系统。基于我们先前的报道，CHRNA 4 rs#1044396 C/T烟碱受体SNP影响视觉空间注意力，但不影响工作记忆，DBH rs#1108580 G/A去甲肾上腺素能酶SNP影响工作记忆，但不影响注意力，我们预测，当两个系统相互作用且工作记忆被注意力操纵时，两种SNP都会调节表现。我们发现，视觉空间注意的规模部署在一个目标影响的记忆的位置，该目标。记忆能力受到两个SNP的调节。CHRNA 4 C/C纯合子和DBH G等位基因携带者表现出最好的记忆表现，但也是视觉空间注意对记忆的最大益处。然而，总的来说，CHRNA 4 SNP比DBH SNP在操纵视觉空间注意力时对记忆表现产生更强的影响。这一证据的综合胆碱能的影响下的注意力操纵工作记忆的表现是一致的工作记忆和视觉空间注意力是独立的系统，可以相互作用的观点。
We investigated the relation between the two systems of visuospatial attention and working memory by examining the effect of normal variation in cholinergic and noradrenergic genes on working memory performance under attentional manipulation. We previously reported that working memory for location was impaired following large location precues, indicating the scale of visuospatial attention has a role in forming the mental representation of the target. In one of the first studies to compare effects of two single nucleotide polymorphisms (SNPs) on the same cognitive task, we investigated the neurotransmission systems underlying interactions between attention and memory. Based on our previous report that the CHRNA4 rs#1044396 C/T nicotinic receptor SNP affected visuospatial attention, but not working memory, and the DBH rs#1108580 G/A noradrenergic enzyme SNP affected working memory, but not attention, we predicted that both SNPs would modulate performance when the two systems interacted and working memory was manipulated by attention. We found the scale of visuospatial attention deployed around a target affected memory for location of that target. Memory performance was modulated by the two SNPs. CHRNA4 C/C homozygotes and DBH G allele carriers showed the best memory performance but also the greatest benefit of visuospatial attention on memory. Overall, however, the CHRNA4 SNP exerted a stronger effect than the DBH SNP on memory performance when visuospatial attention was manipulated. This evidence of an integrated cholinergic influence on working memory performance under attentional manipulation is consistent with the view that working memory and visuospatial attention are separate systems which can interact.
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影响因子：
7.6
作者：
Avery, RA;Franowicz, JS;Arnsten, AFT
通讯作者：
Arnsten, AFT
影响因子：
3.5
作者：
Conway, ARA;Cowan, N;Bunting, MF
通讯作者：
Bunting, MF
影响因子：
4.8
作者：
FOLSTEIN, MF;FOLSTEIN, SE;MCHUGH, PR
通讯作者：
MCHUGH, PR
影响因子：
3.3
作者：
Awh, E;Vogel, EK;Oh, SH
通讯作者：
Oh, SH
影响因子：
2.9
作者：
Espeseth, Thomas;Greenwood, Pameia M.;Parasuraman, Raja
通讯作者：
Parasuraman, Raja