Genetics, environment, and gene-environment interactions in the development of systemic rheumatic diseases.
Genetics, environment, and gene-environment interactions in the development of systemic rheumatic diseases.
复制标题
DOI：
10.1016/j.rdc.2014.07.005
复制
发表时间：
2014-11
影响因子：
2.3
通讯作者：
Costenbader, Karen H.
中科院分区：
文献类型：
--
作者：
Sparks, Jeffrey A.;Costenbader, Karen H.
关键词：
了解疾病易感因素和基因-环境相互作用可能为风湿病病因的生物学机制提供有价值的见解。确定遗传和环境因素在类风湿关节炎（RA）、系统性红斑狼疮（SLE）和强直性脊柱炎（as）等风湿性疾病发病机制中的作用，可能对理解风险预测、致病机制、细胞途径、药物发现和预防策略具有重要意义。然而，由于疾病表型的异质性、低发病率以及遗传和环境因素的地理差异，风湿性疾病给研究人员带来了独特的挑战。新兴的研究领域，包括表观遗传学、代谢组学和微生物组学，可能为风湿性疾病发病机制中的遗传和环境风险因素之间提供额外的联系。本文综述了用于确定遗传和环境风险因素以及研究风湿性疾病中基因-环境相互作用的方法，并提供了确定RA， SLE和AS中基因-环境相互作用的成功和挑战的具体例子。最后，我们描述了新兴的研究策略如何建立在以前的发现以及未来的挑战之上。
Understanding disease susceptibility factors and gene-environment interactions may offer valuable insights into the biological mechanisms for the etiology of rheumatic diseases. Defining the contributions of genetic and environmental factors to the pathogenesis of rheumatic diseases such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and ankylosing spondylitis (AS), may have important implications for understanding risk prediction, pathogenic mechanisms, cellular pathways, drug discovery, and prevention strategies. However, rheumatic diseases offer distinct challenges to researchers due to heterogeneity in disease phenotypes, low disease incidence, and geographic variation in both genetic and environmental factors. Emerging research areas, including epigenetics, metabolomics, and the microbiome, may provide additional links between genetic and environmental risk factors in rheumatic disease pathogenesis. This article reviews the methods used to establish genetic and environmental risk factors and to study gene-environment interactions in rheumatic diseases and provides specific examples of successes and challenges for identifying gene-environment interactions in RA, SLE, and AS. Finally, we describe how emerging research strategies may build upon previous discoveries as well as future challenges.
登录
查看更多内容
影响因子：
--
作者：
Crowson, Cynthia S.;Matteson, Eric L.;Myasoedova, Elena;Michet, Clement J.;Ernste, Floranne C.;Warrington, Kenneth J.;Davis, John M., III;Hunder, Gene G.;Therneau, Terry M.;Gabriel, Sherine E.
通讯作者：
Gabriel, Sherine E.
影响因子：
13.6
作者：
Borchers, Andrea T.;Naguwa, Stanley M.;Gershwin, M. Eric
通讯作者：
Gershwin, M. Eric
DOI：
10.1038/nrrheum.2014.36
发表时间：
2014-07
期刊：
Nature reviews. Rheumatology
影响因子：
--
作者：
通讯作者：
--
影响因子：
8.7
作者：
Colbert RA;DeLay ML;Klenk EI;Layh-Schmitt G
通讯作者：
Layh-Schmitt G
DOI：
10.1002/art.24398
发表时间：
2009-04-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Bernier, Marie-Odile;Mikaeloff, Yann;Suissa, Samy
通讯作者：
Suissa, Samy