Challenges in interpreting cytokine biomarkers in biobehavioral research: a breast cancer exemplar.
Challenges in interpreting cytokine biomarkers in biobehavioral research: a breast cancer exemplar.
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DOI：
10.1177/1099800410383304
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发表时间：
2011-01
影响因子：
2.5
通讯作者：
McCain NL
中科院分区：
文献类型：
--
作者：
Lyon D;Walter J;Munro CL;Schubert CM;McCain NL
This report extends the findings of a prior study comparing the level of plasma cytokines in women with breast cancer to those of women with a benign breast biopsy with the addition of a normal comparison group. The results of this three-group comparison are presented as background for discussing several methodologic challenges for biobehavioral research in inflammatory-based conditions. This study used a descriptive, cross-sectional design to compare the levels of plasma cytokines in women with breast cancer, women with a benign breast biopsy, and a normal comparison group. The levels of 17 cytokines were measured using multiplex bead array assays (Bio-Plex®). Data analysis included a variety of descriptive and graphical techniques to illustrate between-group differences in cytokine profiles. The levels of plasma cytokines in the sample of 35 women who had recently been diagnosed with breast cancer, 24 women with a suspicious breast mass, who subsequently were found to have a benign breast biopsy, and 33 women in a normal comparison group present a background for discussing the implications of extreme between-group differences for biobehavioral nursing research. Both the levels of individual cytokines and their patterns were distinctly different in the three groups. The exemplar presented from the three-group comparison has implications for planning biobehavioral nursing research in patients with conditions characterized by inflammation.
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影响因子：
2.5
作者：
Lyon, Debra E.;McCain, Nancy L.;Schubert, Christine
通讯作者：
Schubert, Christine
影响因子：
27.4
作者：
Hartkamp, A;Geenen, R;Derksen, RHWM
通讯作者：
Derksen, RHWM
影响因子：
5.5
作者：
Mabry, Patricia L.;Olster, Deborah H.;Morgan, Glen D.;Abrams, David B.
通讯作者：
Abrams, David B.
影响因子：
--
作者：
Hanley, Brian P.
通讯作者：
Hanley, Brian P.
DOI：
10.1093/gerona/63.8.879
发表时间：
2008-08
期刊：
The journals of gerontology. Series A, Biological sciences and medical sciences
影响因子：
--
作者：
Leng SX;McElhaney JE;Walston JD;Xie D;Fedarko NS;Kuchel GA
通讯作者：
Kuchel GA