Advances in Resistive Pulse Sensors: Devices bridging the void between molecular and microscopic detection.
Advances in Resistive Pulse Sensors: Devices bridging the void between molecular and microscopic detection.
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DOI：
10.1016/j.nantod.2011.08.012
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发表时间：
2011-10-01
期刊：
影响因子：
17.4
通讯作者：
Trau M
中科院分区：
文献类型：
--
作者：
Kozak D;Anderson W;Vogel R;Trau M
自从1996年首次报道使用生物离子通道来检测单链基因组碱基对的差异以来，纳米级电阻脉冲传感器的复兴随之而来。这种最初在五十多年前概述并商业化的技术的复兴在很大程度上是由纳米级制造的进步以及最终用于基因组测序以及其他大分子表征的快速和廉价手段的前景驱动的。在这种追求中，这些设备的潜在应用，以表征额外的属性，如尺寸，形状，电荷和浓度的纳米级材料（10 - 900 nm）已在很大程度上被忽视。纳米技术和生物技术的进步正在推动对简单而敏感的单个对象读出设备（例如电阻式脉冲传感器）的需求。这篇综述将研究在纳米尺度范围内基于孔的传感的最新进展。详细分析了三种新类型的孔传感器-串联，并联和尺寸可调孔-已被列入。这些孔在更宽的粒度范围内提供了更高的测量灵敏度。这些技术的基本物理化学，这仍在发展中，将进行审查。
Since the first reported use of a biological ion channel to detect differences in single stranded genomic base pairs in 1996, a renaissance in nanoscale resistive pulse sensors has ensued. This resurgence of a technique originally outlined and commercialized over fifty years ago has largely been driven by advances in nanoscaled fabrication, and ultimately, the prospect of a rapid and inexpensive means for genomic sequencing as well as other macromolecular characterization. In this pursuit, the potential application of these devices to characterize additional properties such as the size, shape, charge, and concentration of nanoscaled materials (10 – 900 nm) has been largely overlooked. Advances in nanotechnology and biotechnology are driving the need for simple yet sensitive individual object readout devices such as resistive pulse sensors. This review will examine the recent progress in pore-based sensing in the nanoscale range. A detailed analysis of three new types of pore sensors – in-series, parallel, and size-tunable pores – has been included. These pores offer improved measurement sensitivity over a wider particle size range. The fundamental physical chemistry of these techniques, which is still evolving, will be reviewed.
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