Association between HLA genotypes and COVID-19 susceptibility, severity and progression: a comprehensive review of the literature.
Association between HLA genotypes and COVID-19 susceptibility, severity and progression: a comprehensive review of the literature.
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DOI：
10.1186/s40001-021-00563-1
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发表时间：
2021-08-03
影响因子：
4.2
通讯作者：
Maffulli N
中科院分区：
文献类型：
--
作者：
Migliorini F;Torsiello E;Spiezia F;Oliva F;Tingart M;Maffulli N
COVID-19 大流行对世界各地的文化、政治和经济结构产生了显着影响。其发病机制和相关临床后果的几个方面尚未阐明。各国之间的感染率以及发病率和死亡率各不相同。对于科学家来说，了解患者遗传学如何影响病情的结果、阐明哪些方面可能与 SARS-CoV-2 疾病的临床变异性相关是很有趣的。我们回顾了探索人类白细胞抗原 (HLA) 基因型对 SARS-CoV-2 感染和/或进展的个体反应的作用的研究，还讨论了 MHC 相关免疫模式的贡献。 2021年3月，访问主要在线数据库。所有研究 HLA 基因型和相关多态性与 COVID-19 易感性、严重程度和进展之间可能关联的文章均被考虑。尽管遗传和环境因素肯定会影响个体的易感性或保护性，但 HLA 和相关多态性可以影响 SARS-CoV-2 感染的易感性、进展和严重程度。 HLA 分子在免疫反应中发挥的关键作用，特别是通过病原体衍生的肽呈递，以及人群中 HLA 等位基因的巨大分子变异性可能是导致 COVID-19 感染后不同感染率和不同患者的原因。
The COVID-19 pandemic has markedly impacted on cultural, political, and economic structures all over the world. Several aspects of its pathogenesis and related clinical consequences have not yet been elucidated. Infection rates, as well morbidity and mortality differed within countries. It is intriguing for scientists to understand how patient genetics may influence the outcome of the condition, to clarify which aspects could be related the clinical variability of SARS-CoV-2 disease. We reviewed the studies exploring the role of human leukocyte antigens (HLA) genotypes on individual responses to SARS-CoV-2 infection and/or progression, discussing also the contribution of the immunological patterns MHC-related. In March 2021, the main online databases were accessed. All the articles that investigated the possible association between the HLA genotypes and related polymorphisms with susceptibility, severity and progression of COVID-19 were considered. Although both genetic and environmental factors are certainly expected to influence the susceptibility to or protection of individuals, the HLA and related polymorphisms can influence susceptibility, progression and severity of SARS-CoV-2 infection. The crucial role played by HLA molecules in the immune response, especially through pathogen-derived peptide presentation, and the huge molecular variability of HLA alleles in the human populations could be responsible for the different rates of infection and the different patients following COVID-19 infection.
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影响因子：
4.1
作者：
Falfán-Valencia R;Narayanankutty A;Reséndiz-Hernández JM;Pérez-Rubio G;Ramírez-Venegas A;Nava-Quiroz KJ;Bautista-Félix NE;Vargas-Alarcón G;Castillejos-López MDJ;Hernández A
通讯作者：
Hernández A
影响因子：
6.7
作者：
Fadda L;Körner C;Kumar S;van Teijlingen NH;Piechocka-Trocha A;Carrington M;Altfeld M
通讯作者：
Altfeld M
影响因子：
9.4
作者：
Chen, YMA;Liang, SY;Chu, DC
通讯作者：
Chu, DC
影响因子：
5.6
作者：
Correale, Pierpaolo;Mutti, Luciano;Giordano, Antonio
通讯作者：
Giordano, Antonio
影响因子：
7.4
作者：
Buonaguro, Luigi;Tagliamonte, Maria;Buonaguro, Franco M.
通讯作者：
Buonaguro, Franco M.