An Increased Frequency in HLA Class I Alleles and Haplotypes Suggests Genetic Susceptibility to Influenza A (H1N1) 2009 Pandemic: A Case-Control Study.
An Increased Frequency in HLA Class I Alleles and Haplotypes Suggests Genetic Susceptibility to Influenza A (H1N1) 2009 Pandemic: A Case-Control Study.
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DOI：
10.1155/2018/3174868
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发表时间：
2018
影响因子：
4.1
通讯作者：
Hernández A
中科院分区：
文献类型：
--
作者：
Falfán-Valencia R;Narayanankutty A;Reséndiz-Hernández JM;Pérez-Rubio G;Ramírez-Venegas A;Nava-Quiroz KJ;Bautista-Félix NE;Vargas-Alarcón G;Castillejos-López MDJ;Hernández A
甲型H1N1/09流感大流行感染了少数暴露个体，这表明遗传因素的参与。关于甲型H1N1/09流感大流行与经典HLA I类关联的数据很少。在一项病例对照研究中，我们分析了甲型H1N1/09流感中经典HLA I类等位基因和单倍型的频率，该研究同时招募了138名流感患者（infp）和225名无症状健康接触者（infc）。HLAⅰ类分型采用高分辨率序列分型方法。我们的分析显示，C∗07:02:01,B∗39:06:02,C∗03:02:01,B∗44:03:01，B∗51:01:05和B∗73:01 （p < 0.05; OR = 1.84-9.98）以及A∗68:01:02-C∗07:02:01 （p = 1.05E−05;OR = 23.99）和B∗35:01:01-C∗07:02.01 （p = 4.15E−04,OR = 2.15）两种单倍型在甲型H1N1/09流感受试者中出现的频率更高。A∗68:01:01只存在于INF-P组（5/138）。C∗03:03:01,A∗11:01:01,B∗39:01:01,A∗24:02:01,C∗03:04:01,B∗51:01:01,C∗07:01:01 （p < 0.05, OR = 0.12-0.52）和单倍型A∗02:01:01-B∗35:01:01-C∗04:01:01，A∗24:02:01-B∗35:01:01,B∗39:01:01-C∗07:02:01，B∗40:02:01-C∗03:04:01的频率均降低（p < 0.05, OR = 0.08-0.22）。选择性经典HLA I类等位基因和单倍型组合使个体易患甲型H1N1/09流感大流行。这项工作对获取甲型H1N1/09或未来类似毒株爆发的人群传播风险具有重要意义。
The influenza A H1N1/09 pandemic infected a small number of exposed individuals, which suggests the involvement of genetic factors. There are scarce data available on classical HLA class I association with the influenza A H1N1/09 pandemic. We analyzed the frequency of classical HLA class I alleles and haplotypes in A H1N1/09 influenza in a case-control study including 138 influenza patients (INF-P) and 225 asymptomatic healthy contacts (INF-C) simultaneously recruited. HLA class I typing was performed by high-resolution sequence-based typing method. Our analysis revealed higher frequency of C∗07:02:01, B∗39:06:02, C∗03:02:01, B∗44:03:01, B∗51:01:05, and B∗73:01 (p < 0.05; OR = 1.84–9.98) and of two haplotypes—A∗68:01:02-C∗07:02:01 (p = 1.05E − 05; OR = 23.99) and B∗35:01:01-C∗07:02.01 (p = 4.15E − 04, OR = 2.15)—in A H1N1/09 influenza subjects. A∗68:01:01 was exclusively present only in the INF-P group (5/138). A decrease in the frequency of C∗03:03:01, A∗11:01:01, B∗39:01:01, A∗24:02:01, C∗03:04:01, B∗51:01:01, and C∗07:01:01 (p < 0.05; OR = 0.12–0.52) and of haplotypes A∗02:01:01-B∗35:01:01-C∗04:01:01, A∗24:02:01-B∗35:01:01, B∗39:01:01-C∗07:02:01, and B∗40:02:01-C∗03:04:01 (p < 0.05; OR = 0.08–0.22) were observed in INF-P group. Selective classical HLA class I allele and haplotype combinations predispose individuals towards susceptibility or protection against the influenza A H1N1/09 pandemic. This work has significant implications for accessing population transmission risk for A H1N1/09 or a similar strain breakout in the future.
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