Mega-Analysis of Gray Matter Volume in Substance Dependence: General and Substance-Specific Regional Effects.
Mega-Analysis of Gray Matter Volume in Substance Dependence: General and Substance-Specific Regional Effects.
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DOI：
10.1176/appi.ajp.2018.17040415
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发表时间：
2019-02-01
期刊：
影响因子：
--
通讯作者：
ENIGMA Addiction Working Group
中科院分区：
文献类型：
--
作者：
Mackey S;Allgaier N;Chaarani B;Spechler P;Orr C;Bunn J;Allen NB;Alia-Klein N;Batalla A;Blaine S;Brooks S;Caparelli E;Chye YY;Cousijn J;Dagher A;Desrivieres S;Feldstein-Ewing S;Foxe JJ;Goldstein RZ;Goudriaan AE;Heitzeg MM;Hester R;Hutchison K;Korucuoglu O;Li CR;London E;Lorenzetti V;Luijten M;Martin-Santos R;May A;Momenan R;Morales A;Paulus MP;Pearlson G;Rousseau ME;Salmeron BJ;Schluter R;Schmaal L;Schumann G;Sjoerds Z;Stein DJ;Stein EA;Sinha R;Solowij N;Tapert S;Uhlmann A;Veltman D;van Holst R;Whittle S;Wright MJ;Yücel M;Zhang S;Yurgelun-Todd D;Hibar DP;Jahanshad N;Evans A;Thompson PM;Glahn DC;Conrod P;Garavan H;ENIGMA Addiction Working Group
尽管与非物质依赖对照受试者相比，物质依赖者的大脑体积通常较小，但在不同研究中，大脑体积较小的区域并不一致。此外，目前还不清楚是否有一组共同的区域参与了物质依赖，而不管使用的是什么物质，或者一些脑体积效应是否与物质有关。这些问题的解决可能有助于临床相关成像生物标记物的识别。使用来自14个国家的汇集数据，作者试图确定依赖和区域脑容量之间的一般和特定物质的关联。对来自23个实验室的先前发表的数据进行了大规模分析，其中包括3240人，其中2140人对五种物质中的一种有物质依赖：酒精、尼古丁、可卡因、甲基苯丙胺或大麻。在控制年龄、性别、成像部位和总颅内体积的情况下，将所有采样物质类别组合在一起时，以及单独比较自由冲浪定义的区域的皮质下体积和皮质厚度与非依赖对照受试者。由于酒精依赖具有广泛的关联性，因此对除酒精以外的所有物质的依赖也进行了二次对比。使用优化的对半策略来评估研究结果的可靠性。在有物质依赖的个体中，观察到许多脑区的体积或厚度降低。最大的影响与酒精使用障碍有关。一组与依赖有关的受影响区域，无论是什么物质，都包括脑岛和内侧眶前皮质。此外，区域脑体积的支持向量机多变量分类成功地将对酒精或尼古丁有物质依赖的个体与非依赖对照受试者进行了分类。结果表明，对一系列不同物质的依赖共享一个共同的神经底物，区域体积的不同模式可以作为酒精和尼古丁依赖的有用生物标志物。
Although lower brain volume has been routinely observed in individuals with substance dependence compared with nondependent control subjects, the brain regions exhibiting lower volume have not been consistent across studies. In addition, it is not clear whether a common set of regions are involved in substance dependence regardless of the substance used or whether some brain volume effects are substance specific. Resolution of these issues may contribute to the identification of clinically relevant imaging biomarkers. Using pooled data from 14 countries, the authors sought to identify general and substance-specific associations between dependence and regional brain volumes. Brain structure was examined in a mega-analysis of previously published data pooled from 23 laboratories, including 3,240 individuals, 2,140 of whom had substance dependence on one of five substances: alcohol, nicotine, cocaine, methamphetamine, or cannabis. Subcortical volume and cortical thickness in regions defined by FreeSurfer were compared with nondependent control subjects when all sampled substance categories were combined, as well as separately, while controlling for age, sex, imaging site, and total intracranial volume. Because of extensive associations with alcohol dependence, a secondary contrast was also performed for dependence on all substances except alcohol. An optimized split-half strategy was used to assess the reliability of the findings. Lower volume or thickness was observed in many brain regions in individuals with substance dependence. The greatest effects were associated with alcohol use disorder. A set of affected regions related to dependence in general, regardless of the substance, included the insula and the medial orbitofrontal cortex. Furthermore, a support vector machine multivariate classification of regional brain volumes successfully classified individuals with substance dependence on alcohol or nicotine relative to nondependent control subjects. The results indicate that dependence on a range of different substances shares a common neural substrate and that differential patterns of regional volume could serve as useful biomarkers of dependence on alcohol and nicotine.
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影响因子：
--
作者：
Mackey S;Kan KJ;Chaarani B;Alia-Klein N;Batalla A;Brooks S;Cousijn J;Dagher A;de Ruiter M;Desrivieres S;Feldstein Ewing SW;Goldstein RZ;Goudriaan AE;Heitzeg MM;Hutchison K;Li CS;London ED;Lorenzetti V;Luijten M;Martin-Santos R;Morales AM;Paulus MP;Paus T;Pearlson G;Schluter R;Momenan R;Schmaal L;Schumann G;Sinha R;Sjoerds Z;Stein DJ;Stein EA;Solowij N;Tapert S;Uhlmann A;Veltman D;van Holst R;Walter H;Wright MJ;Yucel M;Yurgelun-Todd D;Hibar DP;Jahanshad N;Thompson PM;Glahn DC;Garavan H;Conrod P
通讯作者：
Conrod P
影响因子：
64.8
作者：
Hibar, Derrek P.;Stein, Jason L.;Renteria, Miguel E.;Arias-Vasquez, Alejandro;Desrivieres, Sylvane;Jahanshad, Neda;Toro, Roberto;Wittfeld, Katharina;Abramovic, Lucija;Andersson, Micael;Aribisala, Benjamin S.;Armstrong, Nicola J.;Bernard, Manon;Bohlken, Marc M.;Boks, Marco P.;Bralten, Janita;Brown, Andrew A.;Chakravarty, M. Mallar;Chen, Qiang;Ching, Christopher R. K.;Cuellar-Partida, Gabriel;den Braber, Anouk;Giddaluru, Sudheer;Goldman, Aaron L.;Grimm, Oliver;Guadalupe, Tulio;Hass, Johanna;Woldehawariat, Girma;Holmes, Avram J.;Hoogman, Martine;Janowitz, Deborah;Jia, Tianye;Kim, Sungeun;Klein, Marieke;Kraemer, Bernd;Lee, Phil H.;Loohuis, Loes M. Olde;Luciano, Michelle;Macare, Christine;Mather, Karen A.;Mattheisen, Manuel;Milaneschi, Yuri;Nho, Kwangsik;Papmeyer, Martina;Ramasamy, Adaikalavan;Risacher, Shannon L.;Roiz-Santianez, Roberto;Rose, Emma J.;Salami, Alireza;Saemann, Philipp G.;Schmaal, Lianne;Schork, Andrew J.;Shin, Jean;Strike, Lachlan T.;Teumer, Alexander;van Donkelaar, Marjolein M. J.;van Eijk, Kristel R.;Walters, Raymond K.;Westlye, Lars T.;Whelan, Christopher D.;Winkler, Anderson M.;Zwiers, Marcel P.;Alhusaini, Saud;Athanasiu, Lavinia;Ehrlich, Stefan;Hakobjan, Marina M. H.;Hartberg, Cecilie B.;Haukvik, Unn K.;Heister, Angelien J. G. A. M.;Hoehn, David;Kasperaviciute, Dalia;Liewald, David C. M.;Lopez, Lorna M.;Makkinje, Remco R. R.;Matarin, Mar;Naber, Marlies A. M.;McKay, D. Reese;Needham, Margaret;Nugent, Allison C.;Puetz, Benno;Royle, Natalie A.;Shen, Li;Sprooten, Emma;Trabzuni, Daniah;van der Marel, Saskia S. L.;van Hulzen, Kimm J. E.;Walton, Esther;Wolf, Christiane;Almasy, Laura;Ames, David;Arepalli, Sampath;Assareh, Amelia A.;Bastin, Mark E.;Brodaty, Henry;Bulayeva, Kazima B.;Carless, Melanie A.;Cichon, Sven;Corvin, Aiden;Curran, Joanne E.;Czisch, Michael;de Zubicaray, Greig I.;Dillman, Allissa;Duggirala, Ravi;Dyer, Thomas D.;Erk, Susanne;Fedko, Iryna O.;Ferrucci, Luigi;Foroud, Tatiana M.;Fox, Peter T.;Fukunaga, Masaki;Gibbs, J. Raphael;Goering, Harald H. H.;Green, Robert C.;Guelfi, Sebastian;Hansell, Narelle K.;Hartman, Catharina A.;Hegenscheid, Katrin;Heinz, Andreas;Hernandez, Dena G.;Heslenfeld, Dirk J.;Hoekstra, Pieter J.;Holsboer, Florian;Homuth, Georg;Hottenga, Jouke-Jan;Ikeda, Masashi;Jack, Clifford R., Jr.;Jenkinson, Mark;Johnson, Robert;Kanai, Ryota;Keil, Maria;Kent, Jack W., Jr.;Kochunov, Peter;Kwok, John B.;Lawrie, Stephen M.;Liu, Xinmin;Longo, Dan L.;McMahon, Katie L.;Meisenzah, Eva;Melle, Ingrid;Mahnke, Sebastian;Montgomery, Grant W.;Mostert, Jeanette C.;Muehleisen, Thomas W.;Nalls, Michael A.;Nichols, Thomas E.;Nilsson, Lars G.;Noethen, Markus M.;Ohi, Kazutaka;Olvera, Rene L.;Perez-Iglesias, Rocio;Pike, G. Bruce;Potkin, Steven G.;Reinvang, Ivar;Reppermund, Simone;Rietschel, Marcella;Romanczuk-Seiferth, Nina;Rosen, Glenn D.;Rujescu, Dan;Schnell, Knut;Schofield, Peter R.;Smith, Colin;Steen, Vidar M.;Sussmann, Jessika E.;Thalamuthu, Anbupalam;Toga, Arthur W.;Traynor, Bryan J.;Troncoso, Juan;Turner, Jessica A.;Valdes Hernandez, Maria C.;van't Ent, Dennis;van der Brug, Marcel;van der Wee, Nic J. A.;van Tol, Marie-Jose;Veltman, Dick J.;Wassink, Thomas H.;Westman, Eric;Zielke, Ronald H.;Zonderman, Alan B.;Ashbrook, David G.;Hager, Reinmar;Lu, Lu;McMahon, Francis J.;Morris, Derek W.;Williams, Robert W.;Brunner, Han G.;Buckner, Randy L.;Buitelaar, Jan K.;Cahn, Wiepke;Calhoun, Vince D.;Cavalleri, Gianpiero L.;Crespo-Facorro, Benedicto;Dale, Anders M.;Davies, Gareth E.;Delanty, Norman;Depondt, Chantal;Djurovic, Srdjan;Drevets, Wayne C.;Espeseth, Thomas;Gollub, Randy L.;Ho, Beng-Choon;Hoffman, Wolfgang;Hosten, Norbert;Kahn, Rene S.;Le Hellard, Stephanie;Meyer-Lindenberg, Andreas;Mueller-Myhsok, Bertram;Nauck, Matthias;Nyberg, Lars;Pandolfo, Massimo;Penninx, Brenda W. J. H.;Roffman, Joshua L.;Sisodiya, Sanjay M.;Smoller, Jordan W.;van Bokhoven, Hans;van Haren, Neeltje E. M.;Voelzke, Henry;Walter, Henrik;Weiner, Michael W.;Wen, Wei;White, Tonya;Agartz, Ingrid;Andreassen, Ole A.;Blangero, John;Boomsma, Dorret I.;Brouwer, Rachel M.;Cannon, Dara M.;Cookson, Mark R.;de Geus, Eco J. C.;Deary, Ian J.;Donohoe, Gary;Fernandez, Guillen;Fisher, Simon E.;Francks, Clyde;Glahn, David C.;Grabe, Hans J.;Gruber, Oliver;Hardy, John;Hashimoto, Ryota;Pol, Hilleke E. Hulshoff;Joensson, Erik G.;Kloszewska, Iwona;Lovestone, Simon;Mattay, Venkata S.;Mecocci, Patrizia;McDonald, Colm;McIntosh, Andrew M.;Ophoff, Roel A.;Paus, Tomas;Pausova, Zdenka;Ryten, Mina;Sachdev, Perminder S.;Saykin, Andrew J.;Simmons, Andy;Singleton, Andrew;Soininen, Hilkka;Wardlaw, Joanna M.;Weale, Michael E.;Weinberger, Daniel R.;Adams, Hieab H. H.;Launer, Lenore J.;Seiler, Stephan;Schmidt, Reinhold;Chauhan, Ganesh;Satizabal, Claudia L.;Becker, James T.;Yanek, Lisa;van der Lee, Sven J.;Ebling, Maritza;Fischl, Bruce;Longstreth, W. T., Jr.;Greve, Douglas;Schmidt, Helena;Nyquist, Paul;Vinke, Louis N.;van Duijn, Cornelia M.;Xue, Luting;Mazoyer, Bernard;Bis, Joshua C.;Gudnason, Vilmundur;Seshadri, Sudha;Ikram, M. Arfan;Martin, Nicholas G.;Wright, Margaret J.;Schumann, Gunter;Franke, Barbara;Thompson, Paul M., Jr.;Medland, Sarah E.
通讯作者：
Medland, Sarah E.
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
Sereno, MI
影响因子：
120.7
作者：
McLellan, AT;Lewis, DC;Kleber, HD
通讯作者：
Kleber, HD
影响因子：
56.9
作者：
Naqvi, Nasir H.;Rudrauf, David;Bechara, Antoine
通讯作者：
Bechara, Antoine