Telmisartan induces growth inhibition, DNA double-strand breaks and apoptosis in human endometrial cancer cells.
Telmisartan induces growth inhibition, DNA double-strand breaks and apoptosis in human endometrial cancer cells.
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DOI：
10.1371/journal.pone.0093050
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Narahara H
中科院分区：
文献类型：
--
作者：
Koyama N;Nishida Y;Ishii T;Yoshida T;Furukawa Y;Narahara H
替米沙坦是一种1型血管紧张素II受体阻滞剂，常用作抗高血压药物，也被表征为过氧化物酶体增殖物激活受体-γ（PPARγ）配体。本研究的目的是阐明替米沙坦对子宫内膜癌细胞的抗肿瘤作用。我们用不同浓度的替米沙坦处理三种子宫内膜癌细胞系，并在体外研究替米沙坦对细胞增殖、凋亡及其相关测量的影响。我们还给予替米沙坦裸鼠实验肿瘤，以确定其在体内的影响和毒性。所有三种子宫内膜癌细胞系都对替米沙坦的生长抑制作用敏感。细胞凋亡的诱导与细胞凋亡相关基因和蛋白表达的改变一致。我们还观察到，DNA双链断裂（DSB）诱导HHUA（人子宫内膜癌）细胞的替米沙坦治疗。此外，裸鼠实验显示，替米沙坦显著抑制人子宫内膜肿瘤生长，且无毒副作用。我们的研究结果表明，替米沙坦可能是治疗子宫内膜癌的一种新的治疗选择。
Telmisartan, an angiotensin II receptor type 1 blocker, is often used as an antihypertension drug, and it has also been characterized as a peroxisome proliferator-activated receptor-gamma (PPARγ) ligand. The purpose of this study was to elucidate the antitumor effects of telmisartan on endometrial cancer cells. We treated three endometrial cancer cell lines with various concentrations of telmisartan, and we investigated the effects of the telmisartan on the cell proliferation, apoptosis, and their related measurements in vitro. We also administered telmisartan to nude mice with experimental tumors to determine its in vivo effects and toxicity. All three endometrial cancer cell lines were sensitive to the growth-inhibitory effect of telmisartan. The induction of apoptosis was confirmed in concert with the altered expression of genes and proteins related to the apoptosis. We also observed that DNA double-strand breaks (DSBs) were induced in HHUA (human endometrial cancer) cells by telmisartan treatment. In addition, experiments in nude mice showed that telmisartan significantly inhibited human endometrial tumor growth, without toxic side effects. Our results suggest that telmisartan might be a new therapeutic option for the treatment of endometrial cancers.
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影响因子：
19
作者：
Hardwick JM;Chen YB;Jonas EA
通讯作者：
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影响因子：
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