Multipolar functions of BCL-2 proteins link energetics to apoptosis.
Multipolar functions of BCL-2 proteins link energetics to apoptosis.
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DOI：
10.1016/j.tcb.2012.03.005
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发表时间：
2012-06
影响因子：
19
通讯作者：
Jonas EA
中科院分区：
文献类型：
--
作者：
Hardwick JM;Chen YB;Jonas EA
经典的凋亡细胞死亡现在已经得到了充分的了解，可以通过数学建模进行研究，并可以通过靶向药物巧妙地操纵以获得临床益处。然而，随着人们认识到凋亡调节因子在功能上是多极的，一个生物学黑洞已经出现。BCL-2家族蛋白对细胞的影响似乎比它们在细胞凋亡中的已知作用更大。虽然这些效应可能只是因为细胞没有死亡而被观察到，但一般的假设是BCL-2蛋白具有尚未发现的生物化学活性。相反，这些尚未表征的日常工作可能是其对细胞存活的深远影响的基础，挑战了目前关于经典凋亡的假设。甚至它们的亚线粒体定位仍然存在争议。在这里，我们试图整合看似矛盾的信息与前景，BCL-2蛋白本身可能是生与死之间的关键串扰。
Classical apoptotic cell death is now sufficiently well understood to be interrogated with mathematical modeling and to be skillfully manipulated with targeted drugs for clinical benefit. However, a biological black hole has emerged with the realization that apoptosis regulators are functionally multipolar. BCL-2 family proteins appear to have much greater effects on cells than can be explained by their known roles in apoptosis. While these effects may be observable simply because the cell is not dead, the general assumption is that BCL-2 proteins have yet undiscovered biochemical activities. Conversely, these yet uncharacterized day-jobs may underlie their profound effects on cell survival, challenging current assumptions about classical apoptosis. Even their sub-mitochondrial localizations remain controversial. Here we attempt to integrate seemingly conflicting information with the prospect that BCL-2 proteins themselves may be the critical crosstalk between life and death.
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影响因子：
11.8
作者：
Arama, E;Agapite, J;Steller, H
通讯作者：
Steller, H
影响因子：
21.3
作者：
通讯作者：
--
影响因子：
4
作者：
Beverly, Levi J.
通讯作者：
Beverly, Levi J.
DOI：
10.1016/j.bbamcr.2010.10.008
发表时间：
2011-04
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Abdelwahid E;Rolland S;Teng X;Conradt B;Hardwick JM;White K
通讯作者：
White K
影响因子：
16
作者：
Chau, BN;Cheng, EHY;Hardwick, JM
通讯作者：
Hardwick, JM