Borrelia burgdorferi and tick proteins supporting pathogen persistence in the vector.
Borrelia burgdorferi and tick proteins supporting pathogen persistence in the vector.
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DOI：
10.2217/fmb.12.121
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发表时间：
2013-01
影响因子：
3.1
通讯作者：
Pal U
中科院分区：
文献类型：
--
作者：
Kung F;Anguita J;Pal U
伯氏疏螺旋体是一种由硬蜱传播的病原体，是导致莱姆病的主要原因，目前还没有人用疫苗。最近，几个B。已经确定了burgdorferi菌株和肩突硬蜱。此外，在开发分子遗传工具以研究病原体和媒介，包括它们之间的复杂关系方面也取得了显著进展。这些进展有助于揭示莱姆病病原体在复杂的地方性感染循环中生存的机制。值得注意的发现已经有助于理解占B的时间和空间表达的螺旋体基因调控。在生命周期的不同阶段中的burgdorferi基因。还发现了一些病原体和载体基因产物，它们有助于微生物的毒力和/或持久性。这些研究方向将丰富我们对媒介传播感染的知识，并有助于制定莱姆病的预防策略。
Borrelia burgdorferi, a pathogen transmitted by Ixodes ticks, is responsible for a prevalent illness known as Lyme disease, and a vaccine for human use is unavailable. Recently, genome sequences of several B. burgdorferi strains and Ixodes scapularis ticks have been determined. In addition, remarkable progress has been made in developing molecular genetic tools to study the pathogen and vector, including their intricate relationship. These developments are helping unravel the mechanisms by which Lyme disease pathogens survive in a complex enzootic infection cycle. Notable discoveries have already contributed to understanding the spirochete gene regulation accounting for the temporal and spatial expression of B. burgdorferi genes during distinct phases of the lifecycle. A number of pathogen and vector gene products have also been identified that contribute to microbial virulence and/or persistence. These research directions will enrich our knowledge of vector-borne infections and contribute towards the development of preventative strategies against Lyme disease.
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影响因子：
3.3
作者：
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通讯作者：
Kotsyfakis M
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3.1
作者：
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作者：
Christophides, GK;Zdobnov, E;Kafatos, FC
通讯作者：
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32.4
作者：
Anguita, J;Ramamoorthi, N;Fikrig, E
通讯作者：
Fikrig, E