Fetal sex is associated with maternal stimulated cytokine production, but not serum cytokine levels, in human pregnancy.
Fetal sex is associated with maternal stimulated cytokine production, but not serum cytokine levels, in human pregnancy.
复制标题
DOI：
10.1016/j.bbi.2016.06.015
复制
发表时间：
2017-03
期刊：
影响因子：
--
通讯作者：
Christian LM
中科院分区：
文献类型：
--
作者：
Mitchell AM;Palettas M;Christian LM
Some studies suggest that fetal sex plays a role in maternal physiological processes during pregnancy including glycemic control, blood pressure, and cortisol regulation. However, data examining fetal sex-specific differences in maternal immune parameters is lacking. In the current study, serum levels of interleukin(IL)-6, IL-8, and tumor necrosis factor(TNF)-α as well as LPS-stimulated production of IL-6, IL-8, TNF-α, and IL-1β by PBMCs incubated for 24 h were assessed in early, mid, and late pregnancy among 80 women (46 with male and 34 with female fetuses). Linear mixed models showed that women carrying females versus males exhibited greater stimulated production of IL-6 at each timepoint (ps ≤ 0.03), TNF-α in early pregnancy (p = 0.04), and IL-1β in mid- and late pregnancy (ps ≤ 0.05). Despite changes in serum levels of IL-8 (p = 0.002) and TNF-α (p < 0.0001) across pregnancy, no differences in any serum cytokines were observed in relation to fetal sex (ps > 0.85). In conclusion, in pregnant women, those carrying female versus male fetuses exhibited greater stimulated cytokine production across pregnancy. Differential inflammatory responses could affect maternal health and fetal development. Fetal sex should be considered as a factor in studies of maternal inflammation. These findings have relevance both clinically and conceptually. For example, maternal asthma is exacerbated among women carrying female versus male fetuses. In addition, data on associations between fetal sex and maternal immune function among women with health conditions (e.g., preeclampsia) and adverse pregnancy outcomes (e.g., preterm birth) would be informative.
登录
查看更多内容
影响因子：
4.4
作者：
Larcombe AN;Foong RE;Bozanich EM;Berry LJ;Garratt LW;Gualano RC;Jones JE;Dousha LF;Zosky GR;Sly PD
通讯作者：
Sly PD
影响因子：
3.8
作者：
Christian, Lisa M.;Porter, Kyle
通讯作者：
Porter, Kyle
影响因子：
--
作者：
Bursac, Zoran;Gauss, C Heath;Williams, David Keith;Hosmer, David W
通讯作者：
Hosmer, David W
DOI：
10.1038/nri2394
发表时间：
2008-09
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Fish EN
通讯作者：
Fish EN
影响因子：
24.3
作者：
Kips, JC
通讯作者：
Kips, JC