Longitudinal changes in serum proinflammatory markers across pregnancy and postpartum: effects of maternal body mass index.
Longitudinal changes in serum proinflammatory markers across pregnancy and postpartum: effects of maternal body mass index.
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DOI：
10.1016/j.cyto.2014.06.018
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发表时间：
2014-12
期刊：
影响因子：
3.8
通讯作者：
Porter, Kyle
中科院分区：
文献类型：
--
作者：
Christian, Lisa M.;Porter, Kyle
母亲的免疫系统会发生重大变化，以支持健康的妊娠。虽然肥胖是炎症的主要驱动因素，也是围产期并发症的预测因素，但妊娠和肥胖对炎症过程变化的叠加效应尚未得到很好的描述。本研究检测了57名妇女在妊娠各期和产后4-6周的血清促炎标志物白细胞介素（IL）-6，IL-8，肿瘤坏死因子（TNF）-α，IL-1β和C-反应蛋白（CRP）。总体而言，IL-6在整个妊娠期间呈增加趋势，并在产后显著增加。同样，TNF-α在整个妊娠期显著增加，产后进一步增加。IL-8和IL-1β均呈“U”型曲线，从妊娠早期到晚期逐渐降低，产后逐渐升高。最后，血清CRP在整个妊娠期间显著降低，产后进一步降低。每次研究访视时，母亲肥胖预示着较高的IL-6。肥胖妇女在怀孕期间血清CRP水平有升高的趋势，产后血清CRP水平明显升高。妊娠和产后过程的特点是血清促炎介质的显着变化。肥胖妇女在怀孕期间和产后显示血清促炎标志物相对于正常体重妇女升高。需要进一步的研究来确定肥胖引起的炎症对母亲和胎儿健康的影响程度。
The maternal immune system undergoes substantial changes to support healthy pregnancy. Although obesity is a primary driver of inflammation and predictive of perinatal complications, additive effects of pregnancy and obesity on changes in inflammatory processes are not well delineated. This study examined serum proinflammatory markers interleukin(IL)-6, IL-8, tumor necrosis factor(TNF)-α, IL-1β, and C-reactive protein(CRP) during each trimester of pregnancy and 4-6 weeks postpartum among 57 women. Overall, IL-6 showed an increasing trend across pregnancy and significant increase at postpartum. Similarly, TNF-α increased significantly across gestation, with a further increase at postpartum. Both IL-8 and IL-1β showed a U-shaped curve, decreasing from early to later pregnancy, and increasing at postpartum. Finally, serum CRP decreased significantly across pregnancy, with further decreases at postpartum. Maternal obesity predicted higher IL-6 at each study visit. Obese women showed a trend toward elevated serum CRP during pregnancy, and significantly higher levels at postpartum. The course of pregnancy and postpartum is characterized by significant changes in serum proinflammatory mediators. Obese women show elevations in serum proinflammatory markers relative to normal weight women during pregnancy and postpartum. Further research is needed to determine the extent to which obesity-induced inflammation affects maternal and fetal health.
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DOI：
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发表时间：
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影响因子：
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