Candidate gustatory interneurons modulating feeding behavior in the Drosophila brain.
Candidate gustatory interneurons modulating feeding behavior in the Drosophila brain.
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DOI：
10.1371/journal.pbio.0030305
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发表时间：
2005-09
期刊：
影响因子：
9.8
通讯作者：
Pankratz MJ
中科院分区：
文献类型：
--
作者：
Melcher C;Pankratz MJ
摄食是所有动物的一项基本活动，可以通过内部能量状态或外部感官信号来调节。我们已经鉴定了一种锌指转录因子，klumpfuss (klu)，这是果蝇幼虫摄取食物所必需的。微阵列分析表明，在klu突变体中，大脑中神经肽基因hugin （hug）的表达发生了改变，hug本身受食物信号的调节。神经解剖学分析表明，表达拥抱的神经元将轴突投射到咽肌、中枢神经内分泌器官和高级脑中枢，而拥抱树突则由表达外部味觉受体的神经元以及咽内化学感觉器官支配。利用破伤风毒素阻断拥抱神经元的突触传递，导致进食起始的改变，这取决于先前的营养状况。我们的研究结果提供了证据，表明拥抱神经元在调节味觉介导的进食行为的神经回路中起作用。表达神经肽的神经元将味觉输入与高级脑中枢相互连接，调节果蝇的摄食行为
Feeding is a fundamental activity of all animals that can be regulated by internal energy status or external sensory signals. We have characterized a zinc finger transcription factor, klumpfuss (klu), which is required for food intake in Drosophila larvae. Microarray analysis indicates that expression of the neuropeptide gene hugin (hug) in the brain is altered in klu mutants and that hug itself is regulated by food signals. Neuroanatomical analysis demonstrates that hug-expressing neurons project axons to the pharyngeal muscles, to the central neuroendocrine organ, and to the higher brain centers, whereas hug dendrites are innervated by external gustatory receptor-expressing neurons, as well as by internal pharyngeal chemosensory organs. The use of tetanus toxin to block synaptic transmission of hug neurons results in alteration of food intake initiation, which is dependent on previous nutrient condition. Our results provide evidence that hug neurons function within a neural circuit that modulates taste-mediated feeding behavior. Neuropeptide expressing neurons interconnecting taste input with higher brain centers modulate feeding behavior in Drosophila
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