Multifaceted effects of antimetabolite and anticancer drug, 2‐deoxyglucose on eukaryotic cancer models budding and fission yeast
Multifaceted effects of antimetabolite and anticancer drug, 2‐deoxyglucose on eukaryotic cancer models budding and fission yeast
复制标题
抗代谢物和抗癌药物 2-脱氧葡萄糖对真核癌症模型芽殖和裂殖酵母的多方面影响
DOI：
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
C. J. D'Souza
中科院分区：
文献类型：
--
作者：
A. Vishwanatha;C. J. D'Souza
糖酵解抑制剂在治疗上是令人感兴趣的，因为它们对显示出增加的糖酵解速率和线粒体缺陷的癌症有效。2-脱氧葡萄糖（2-DG）是一种糖酵解抑制剂，被鉴定为葡萄糖的竞争性抑制剂。过去几十年的研究表明，2-DG的作用机制很复杂，涉及多种代谢和信号通路。芽殖酵母酿酒酵母和裂殖酵母粟酒裂殖酵母是研究代谢、细胞周期和细胞信号转导的两种重要模型。这两种单细胞真核生物是Crabtree阳性酵母，表现出与癌细胞相似的代谢。由于这些相似性，2-DG在酵母中的作用令人感兴趣，因此酵母已成为研究2-DG作用模式和抗性的理想模式生物。本文综述了2-DG在芽殖酵母和裂殖酵母中的生物学效应和耐药性，并对其作为了解癌症代谢和影响癌症进展的药物模型的可能作用机制进行了深入探讨。© 2017 IUBMB Life，69（3）：137-147，2017
Glycolytic inhibitors are of interest therapeutically as they are effective against cancers that display increased glycolytic rate and mitochondrial defects. 2‐Deoxyglucose (2‐DG) is one such glycolytic inhibitor and was identified to be a competitive inhibitor of glucose. Studies from past few decades have shown that the mechanism of action of 2‐DG is complex involving several metabolic and signaling pathways. Budding yeast Saccharomyces cerevisiae and fission yeast Schizosaccharomyces pombe are two important models for studying metabolism, cell cycle and cell signaling. These two unicellular eukaryotes are Crabtree positive yeasts exhibiting a metabolism similar to that of cancer cells. Effects of 2‐DG in yeast is of interest owing to these similarities and hence yeasts have emerged as ideal model organisms to study the mode of action and resistance to 2‐DG. In this review, we summarize the studies on biological effect and resistance to 2‐DG in budding and fission yeasts and give an insight into its possible mechanism of action as models for understanding cancer metabolism and drugs affecting cancer progression. © 2017 IUBMB Life, 69(3):137–147, 2017
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影响因子：
11.2
作者：
Pelicano H;Lu W;Zhou Y;Zhang W;Chen Z;Hu Y;Huang P
通讯作者：
Huang P
影响因子：
3.3
作者：
L. Neigeborn;M. Carlson
通讯作者：
L. Neigeborn;M. Carlson
影响因子：
50.3
作者：
Ward PS;Thompson CB
通讯作者：
Thompson CB
影响因子：
3.9
作者：
Hoffman, CS
通讯作者：
Hoffman, CS