Epoprostenol-associated pneumonitis: diagnostic use of a T-cell proliferation assay.
Epoprostenol-associated pneumonitis: diagnostic use of a T-cell proliferation assay.
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DOI：
10.1016/j.healun.2010.04.023
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发表时间：
2010-09
期刊：
影响因子：
--
通讯作者：
De Jesus Perez V
中科院分区：
文献类型：
--
作者：
Kudelko KT;Nadeau K;Leung AN;Liu J;Haddad F;Zamanian RT;De Jesus Perez V
We describe a case of severe drug-induced interstitial pneumonitis in a woman with idiopathic pulmonary arterial hypertension on epoprostenol confirmed by a drug T cell proliferation assay. Proliferation assays were carried out in our patient and a healthy control. Isolated T cells were incubated with CD3-depleted peripheral blood mononuclear cells and then stimulated to proliferate with 3H-thymidine in the presence of epoprostenol, other prostanoid analogs, and controls. A significant (P < 0.001) T cell proliferation response occurred in our patient in the presence of epoprostenol alone. There was a trend towards an increased T cell response to treprostinil but this was statistically insignificant (P=NS). There was no significant T cell response either to the diluent alone, normal saline, iloprost or alprostadil. There was no significant proliferation to any drug in the healthy control. Hence, a drug T cell proliferation assay confirmed that epoprostenol can rarely incite a profound inflammatory response in the pulmonary interstitium.
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DOI：
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发表时间：
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期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
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