The subiculum sensitizes retrosplenial cortex layer 2/3 pyramidal neurons
The subiculum sensitizes retrosplenial cortex layer 2/3 pyramidal neurons
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下托使压后皮质层 2/3 锥体神经元敏感
DOI：
10.1113/jp281152
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Ikegaya Yuji
中科院分区：
文献类型：
--
作者：
Gao Mengxuan;Noguchi Asako;Ikegaya Yuji
关键点压后皮质（RSC）是一个与各种大脑区域突触连接的大脑区域，已知RSC中的神经元会根据海马尖波-波纹增加神经元活动。颗粒RSC（gRSC）中的锥体细胞2/3层，但不是第5层，响应于阶跃脉冲电流注入，显示出缓慢的斜坡去极化和相当延迟的尖峰。RSC层2/3锥体神经元被前一个电流注入缩短.这种效应被来自下托的轴突传入的激活所模拟，但不被新皮层传入的激活所模拟.下托可能促进RSC中的信息处理和流动.摘要压后皮层（RSC）是一个涉及多种认知功能的大脑区域，是一个与不同脑区形成单突触联系的解剖枢纽.在这里，我们报告了一种独特的形式的短期内在可塑性在小鼠颗粒RSC层2/3锥体细胞。这些细胞表现出延迟尖峰体细胞电流注入，但尖峰潜伏期缩短了前一个简短的去极化（引发）。这种引发诱导的敏化与脱敏不同，脱敏通常在其他皮层神经元中观察到。易化启动效应持续时间超过3 s，为RSC输入的敏感性增加提供了一个时间窗口。基于轴突纤维的光遗传学刺激后的vitroandin vivopatch-clamp记录，我们发现下托传入的预激活复制了易化启动效应。结果表明，对RSC 2/3层神经元的下丘脑输入可能调节RSC 2/3层回路中随后的信息整合。
Key pointsNeurons in the retrosplenial cortex (RSC), a cerebral region that connects synaptically with various brain regions, are known to increase neuronal activity in accordance with hippocampal sharp wave‐ripples.Pyramidal cells in granular RSC (gRSC) layer 2/3, but not layer 5, exhibit slowly ramping depolarization and considerably delayed spikes in response to a step‐pulse current injection.The latencies of delayed spikes in RSC layer 2/3 pyramidal neurons were shortened by a preceding current injection.This effect was mimicked by activation of axonal afferents from the subiculum, but not of neocortical afferents.The subiculum is likely to facilitate information processing and flow in the RSC.AbstractThe retrosplenial cortex (RSC), a cerebral region involved in diverse cognitive functions, is an anatomical hub that forms monosynaptic connections with various brain areas. Here, we report a unique form of short‐term intrinsic plasticity in mouse granular RSC layer 2/3 pyramidal cells. These cells exhibited delayed spikes in response to somatic current injection, but the spike latencies were shortened by a preceding brief depolarization (priming). This priming‐induced sensitization is distinct from desensitization, which is commonly observed in other cortical neurons. The facilitatory priming effect lasted for more than 3 s, providing a time window for increased sensitivity to RSC inputs. Based onin vitroandin vivopatch‐clamp recordings following optogenetic stimulation of axonal fibres, we found that preactivation of subicular afferents replicated the facilitatory priming effect. The results suggest that subicular inputs to RSC layer 2/3 neurons may modulate subsequent information integration in the RSC layer 2/3 circuits.
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DOI：
10.1085/jgp.201311015
发表时间：
2013-10
期刊：
The Journal of general physiology
影响因子：
--
作者：
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通讯作者：
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影响因子：
2
作者：
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影响因子：
3.7
作者：
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通讯作者：
N. Yamawaki;K. Corcoran;A. Guedea;G. Shepherd;J. Radulovic
影响因子：
64.5
作者：
Hattori, Ryoma;Danskin, Bethanny;Komiyama, Takaki
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DOI：
--
发表时间：
2014
期刊：
影响因子：
--
作者：
Donald Elmazi;Tetsuya Oda;Evjola Spaho;Elis Kulla;Leonard Barolli;舟山健太
通讯作者：
舟山健太