Activation of Bcl-2 promoter-directed gene expression by the human immunodeficiency virus type-1 Tat protein.
Activation of Bcl-2 promoter-directed gene expression by the human immunodeficiency virus type-1 Tat protein.
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人类免疫缺陷病毒 1 型 Tat 蛋白激活 Bcl-2 启动子指导的基因表达。
DOI：
10.1006/viro.1999.9688
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发表时间：
1999
期刊：
影响因子：
3.7
通讯作者：
Morris,CB
中科院分区：
文献类型：
--
作者：
Wang,Z;Morris,GF;Reed,JC;Kelly,GD;Morris,CB
Human immunodeficiency virus type 1 (HIV-1) Tat transcriptionally activates expression from a number of viral and cellular promoters. Recent studies demonstrate the ability of Tat to differentially modulate cellular responses to apoptotic signaling. The antiapoptotic effects of Tat appear to correlate with increased expression of Bcl-2, a cellular protein that enhances cellular survival. Here, endogenous expression of HIV-1 Tat in HeLa and Jurkat cells elevates levels of Bcl-2. Transient expression assays performed in HeLa cells demonstrate that Tat directly or indirectly enhances Bcl-2 promoter-directed gene expression by more than 10-fold. Analyses of Tat mutants demonstrate that two noncontiguous regions in the N- and C-termini of Tat mediate maximal transactivation of the Bcl-2 promoter. The requirement for C-terminal sequences contrasts with transactivation of the HIV-1 long terminal repeat in which the N-terminal 57 amino acids are required but downstream residues are not. Bcl-2 promoter analyses suggest that sequences required for Tat responsiveness are located upstream of P1 and between the P1 and P2 promoter units. Results from these studies reveal effects of HIV-1 Tat on Bcl-2 expression and provide a putative mechanism by which endogenously expressed Tat affects cellular survival through the up-regulation of Bcl-2.
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DOI：
10.1073/pnas.92.16.7312
发表时间：
1995-08
影响因子：
11.1
作者：
B. Nardelli;C. Gonzalez;M. Schechter;F. Valentine
通讯作者：
B. Nardelli;C. Gonzalez;M. Schechter;F. Valentine
人类免疫缺陷病毒 I 型 tat 的表达导致 bcl-2 下调并诱导造血细胞凋亡。
影响因子：
8
作者：
J. Sastry;M. Marin;P. Nehete;K. McConnell;A. El;T. McDonnell
通讯作者：
T. McDonnell
转录因子 Egr-1 抑制人纤维肉瘤细胞生长涉及 Bcl-2 的下调
影响因子：
6.4
作者：
R. Huang;Y. Fan;A. Peng;Z. Zeng;John Calvin Reed;E. Adamson;A. Boynton
通讯作者：
A. Boynton
影响因子：
56.9
作者：
Emerman, M;Malim, MH
通讯作者：
Malim, MH
人类免疫缺陷病毒 1 型 tat 通过小鼠 c-myc 基因内的减毒位点指导转录。
影响因子：
5.6
作者：
S. Wright;X. Lu;B. Peterlin
通讯作者：
B. Peterlin