The cerebrospinal fluid: regulator of neurogenesis, behavior, and beyond.

The cerebrospinal fluid: regulator of neurogenesis, behavior, and beyond.
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DOI:
10.1007/s00018-012-0957-x
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发表时间:
2012-09
影响因子:
8
通讯作者:
Lehtinen, Maria K.
Lehtinen, Maria K.
中科院分区:
生物学1区
文献类型:
--
作者:
Zappaterra, Mauro W.;Lehtinen, Maria K.

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脑脊液(CSF)作为一种调节大脑发育、动态平衡和疾病的活跃信号环境,重新引起了人们的兴趣。蛋白质组学研究的进展使人们能够更好地描述从发育到成年期的脑脊液,通过脑脊液传递的关键神经源性信号通路现在正在被阐明。由于它与发育中的和成人大脑中的神经干细胞直接接触,脑脊液能够在中枢神经系统中迅速传递信号,这为新的和令人兴奋的治疗方法开辟了道路。在这篇综述中,我们将讨论脉络丛-脑脊液系统的发展,并回顾目前关于脑脊液如何积极调节哺乳动物脑发育、行为和对创伤性脑损伤的反应的文献。
The cerebrospinal fluid (CSF) has attracted renewed interest as an active signaling milieu that regulates brain development, homeostasis, and disease. Advances in proteomics research have enabled an improved characterization of the CSF from development through adulthood, and key neurogenic signaling pathways that are transmitted via the CSF are now being elucidated. Due to its immediate contact with neural stem cells in the developing and adult brain, the CSF's ability to swiftly distribute signals across vast distances in central nervous system is opening avenues to novel and exciting therapeutic approaches. In this review, we will discuss the development of the choroid plexus-CSF system, and review the current literature on how the CSF actively regulates mammalian brain development, behavior, and responses to traumatic brain injury.
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