Smoking is associated with worse outcomes of COVID-19 particularly among younger adults: a systematic review and meta-analysis.
Smoking is associated with worse outcomes of COVID-19 particularly among younger adults: a systematic review and meta-analysis.
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DOI：
10.1186/s12889-021-11579-x
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发表时间：
2021-08-16
影响因子：
4.5
通讯作者：
Glantz SA
中科院分区：
文献类型：
--
作者：
Patanavanich R;Glantz SA
吸烟损害肺部免疫功能，损害上呼吸道，增加感染传染病的风险和严重程度。本文量化了吸烟与COVID-19疾病进展之间的关联。我们在PubMed和Embase中检索了2020年1月1日至5月25日发表的研究。我们纳入了报告COVID-19患者吸烟行为和疾病进展（包括死亡）的研究。我们使用随机效应荟萃分析，荟萃回归和局部加权回归和平滑来检查数据中的关系。我们发现了46篇同行评审论文，共有22，939名COVID-19患者，其中5421名（23.6%）出现疾病进展，2914名（12.7%）有吸烟史（当前和既往吸烟者）。在有吸烟史的人群中，33.5%的人经历了疾病进展，而非吸烟者为21.9%。荟萃分析证实了吸烟与COVID-19进展之间的相关性（OR 1.59，95% CI 1.33-1.89，p = 0.001）。曾经吸烟与COVID-19死亡风险增加相关（OR 1.19，95% CI 1.02-1.39，p = 0.003）。我们发现，在调整和未调整的分析之间，曾经吸烟对COVID-19疾病进展的影响没有显著差异（p = 0.864），表明吸烟是COVID-19疾病进展的独立风险因素。我们还发现，年轻人中COVID-19进展的风险更高（p = 0.001），在45岁以下的年轻人中效果最明显。吸烟是导致COVID-19进展（包括死亡）的独立风险。这种影响在年轻人中似乎更大。在COVID-19大流行期间，预防和戒烟仍应是公众、医生和公共卫生专业人员的优先事项。在线版本包含补充材料，可通过10.1186/s12889-021-11579-x获得。
Smoking impairs lung immune function and damages upper airways, increasing risks of contracting and severity of infectious diseases. This paper quantifies the association between smoking and COVID-19 disease progression. We searched PubMed and Embase for studies published from January 1–May 25, 2020. We included studies reporting smoking behavior of COVID-19 patients and progression of disease, including death. We used random effects meta-analysis, meta-regression and locally weighted regression and smoothing to examine relationships in the data. We identified 46 peer-reviewed papers with a total of 22,939 COVID-19 patients, 5421 (23.6%) experienced disease progression and 2914 (12.7%) with a history of smoking (current and former smokers). Among those with a history of smoking, 33.5% experienced disease progression, compared with 21.9% of non-smokers. The meta-analysis confirmed an association between ever smoking and COVID-19 progression (OR 1.59, 95% CI 1.33–1.89, p = 0.001). Ever smoking was associated with increased risk of death from COVID-19 (OR 1.19, 95% CI 1.02–1.39, p = 0.003). We found no significant difference (p = 0.864) between the effects of ever smoking on COVID-19 disease progression between adjusted and unadjusted analyses, suggesting that smoking is an independent risk factor for COVID-19 disease progression. We also found the risk of having COVID-19 progression higher among younger adults (p = 0.001), with the effect most pronounced among younger adults under about 45 years old. Smoking is an independent risk for having progression of COVID-19, including mortality. The effects seem to be higher among young people. Smoking prevention and cessation should remain a priority for the public, physicians, and public health professionals during the COVID-19 pandemic. The online version contains supplementary material available at 10.1186/s12889-021-11579-x.
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DOI：
10.1093/geronb/gbaa074
发表时间：
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影响因子：
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作者：
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