Relationship between Autistic Spectrum Trait and Regional Cerebral Blood Flow in Healthy Male Subjects-猫眼课题宝

健康男性受试者自闭症谱系特征与局部脑血流的关系

DOI：

发表时间：

2018

期刊：

Psychiatry Investigation

影响因子：

2.7

通讯作者：

中科院分区：

医学4区

文献类型：

作者：

M. Ota;J. Matsuo;N. Sato;T. Teraishi;H. Hori;K. Hattori;Y. Kamio;N. Maikusa;H. Matsuda;H. Kunugi

目的自闭症谱系特征被认为是一个连续体，它介于自闭症个体和正常发育个体之间。本研究旨在探讨与孤独症谱系特征相关的功能和网络异常。方法受试者为41名健康男性受试者，接受成人社会反应量表（SRS-A）和磁共振成像检查。结果SRS-A总分与后扣带皮层（PCC）局部脑血流量（CBF）呈显著正相关。扣带回、海马、梭状皮质等功能网络也发生了变化。此外，我们还发现，高和低自闭症谱系特质的健康男性受试者之间的功能网络的显着差异，这些点是一致的，从自闭症谱系障碍的先前的看法。结论这些结果为孤独症谱系特征提供了生物学基础，并可作为孤独症谱系学的影像学标记物。

Objective Autistic spectrum traits are postulated to lie on a continuum that extends between individuals with autism and individuals with typical development. The present study was carried out to investigate functional and network abnormalities associated with autistic spectrum trait in healthy male subjects. Methods Subjects were 41 healthy male subjects who underwent the social responsiveness scale-adult (SRS-A) and magnetic resonance imaging. Results There was significant positive correlation between the total score of SRS-A and the regional cerebral blood flow (CBF) in posterior cingulate cortex (PCC). Also, there were changes in functional network such as in cingulate corti, insula and fusiform cortex. Further, we also found the significant difference of functional networks between the healthy male subjects with high or low autistic spectrum trait, and these points were congruent with the previous perceptions derived from autistic-spectrum disorders. Conclusion These findings suggest a biological basis for the autistic spectrum trait and may be useful for the imaging marker of autism symptomatology.