Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery.
Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery.
复制标题
用于基于热疗的治疗和受控药物递送的磁纳米材料。
DOI：
10.1016/j.addr.2011.03.008
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发表时间：
2011-08-14
影响因子：
16.1
通讯作者：
Mohammad, Faruq
中科院分区：
文献类型：
--
作者：
Kumar, Challa S. S. R.;Mohammad, Faruq
关键词：
以往关于磁性纳米材料用于热疗的文献综述主要集中在使用单金属/金属氧化物纳米颗粒的磁流体热疗(MFH)上。文献中的“热疗”一词也仅限于用于治疗应用的热疗。最近，有许多文献表明，基于磁性纳米颗粒的热疗可以产生局部热，从而导致药物要么结合到磁性纳米颗粒上，要么被包裹在聚合物基质中。在这篇综述文章中，我们提出了一个案例，通过包括热疗和磁调制受控药物输送来扩大术语“热疗”的含义。我们将热疗药物控释分为基于热疗的药物控释(DBB)和基于热疗的增透药物控释(DEP)。该综述还首次涉及核壳型磁性纳米材料，特别是利用层层自组装制备的纳米壳，用于基于热疗的治疗和受控药物输送的应用。这篇综述文章的重点是描述基于热疗的治疗和受控药物释放范例相结合的潜在机会，以成功应用于个性化药物。
Previous attempts to review the literature on magnetic nanomaterials for hyperthermia-based therapy focused primarily on magnetic fluid hyperthermia (MFH) using mono metallic/metal oxide nanoparticles. The term “Hyperthermia” in the literature was also confined only to include use of heat for therapeutic applications. Recently, there have been a number of publications demonstrating magnetic nanoparticle-based hyperthermia to generate local heat resulting in the release of drugs either bound to the magnetic nanoparticle or encapsulated within polymeric matrices. In this review article, we present a case for broadening the meaning of the term “hyperthermia” by including thermotherapy as well as magnetically modulated controlled drug delivery. We provide a classification for controlled drug delivery using hyperthermia: Hyperthermia-based controlled Drug delivery through Bond Breaking (DBB) and Hyperthermia-based controlled Drug delivery through Enhanced Permeability (DEP). The review also covers, for the first time, core-shell type magnetic nanomaterials, especially nanoshells prepared using layer-by-layer self-assembly, for the application of hyperthermia-based therapy and controlled drug delivery. The highlight of the review article is to portray potential opportunities in the combination of hyperthermia-based therapy and controlled drug release paradigms for successful application in personalized medicine.
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影响因子：
4.9
作者：
Alexis F;Pridgen E;Molnar LK;Farokhzad OC
通讯作者：
Farokhzad OC
影响因子：
2.7
作者：
Chatterjee, J;Bettge, M;Chen, CJ
通讯作者：
Chen, CJ
DOI：
10.1524/zpch.2006.220.1.3
发表时间：
2006-01-01
影响因子：
2.5
作者：
Behrens, S;Bönnemann, H;Guldbakke, JM
通讯作者：
Guldbakke, JM
影响因子：
3.9
作者：
Chen, Shu;Li, Ying;Liu, Hui-Zhou
通讯作者：
Liu, Hui-Zhou
影响因子：
2.7
作者：
Chalkidou, A.;Simeonidis, K.;Kalogirou, O.
通讯作者：
Kalogirou, O.