Role of matrix metalloproteinases in multi-system inflammatory syndrome and acute COVID-19 in children.
Role of matrix metalloproteinases in multi-system inflammatory syndrome and acute COVID-19 in children.
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DOI：
10.3389/fmed.2022.1050804
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发表时间：
2022
影响因子：
3.9
通讯作者：
中科院分区：
文献类型：
--
作者：
儿童多系统炎症综合征（MIS-C）是SARS冠状病毒2（SARS-CoV 2）感染后的严重炎症后遗症。MIS-C的发病机制尚不明确，基质金属蛋白酶（MMPs）可能起重要作用。基质金属蛋白酶（MMP）是许多疾病中肺病理学的已知驱动因素。为了阐明MMPs在儿童COVID-19发病机制中的作用，我们检测了MIS-C和急性COVID-19儿童的MMPs血浆水平，并将其与恢复期COVID-19和其他常见热带疾病儿童（临床表现重叠）进行了比较。与急性COVID-19、其他热带疾病（登革热、伤寒和恙虫病）和恢复期COVID-19儿童相比，MIS-C儿童的MMP水平升高（P < 0.005，具有统计学显著性）。PCA和ROC分析（敏感性84-100%，特异性80-100%）显示，MMP-8，12，13可以帮助区分MIS-C与急性COVID-19和其他热带疾病，具有较高的敏感性和特异性。在MIS-C儿童中，与不需要重症监护的儿童相比，需要重症监护病房的儿童MMPs水平升高。当将患有重度/中度COVID-19的儿童与患有轻度COVID-19的儿童进行比较时，也注意到了类似的发现。最后，MMP水平与实验室参数（包括淋巴细胞计数、CRP、D-二聚体、铁蛋白和钠水平）显著相关。我们的研究结果表明，MMPs在儿童MIS-C和COVID-19的发病机制中起着关键作用，可能有助于区分MIS-C与其他具有重叠临床表现的疾病。
Multisystem Inflammatory Syndrome in children (MIS-C) is a serious inflammatory sequela of SARS-CoV2 infection. The pathogenesis of MIS-C is vague and matrix metalloproteinases (MMPs) may have an important role. Matrix metalloproteinases (MMPs) are known drivers of lung pathology in many diseases. To elucidate the role of MMPs in pathogenesis of pediatric COVID-19, we examined their plasma levels in MIS-C and acute COVID-19 children and compared them to convalescent COVID-19 and children with other common tropical diseases (with overlapping clinical manifestations). Children with MIS-C had elevated levels of MMPs (P < 0.005 statistically significant) in comparison to acute COVID-19, other tropical diseases (Dengue fever, typhoid fever, and scrub typhus fever) and convalescent COVID-19 children. PCA and ROC analysis (sensitivity 84–100% and specificity 80–100%) showed that MMP-8, 12, 13 could help distinguish MIS-C from acute COVID-19 and other tropical diseases with high sensitivity and specificity. Among MIS-C children, elevated levels of MMPs were seen in children requiring intensive care unit admission as compared to children not needing intensive care. Similar findings were noted when children with severe/moderate COVID-19 were compared to children with mild COVID-19. Finally, MMP levels exhibited significant correlation with laboratory parameters, including lymphocyte counts, CRP, D-dimer, Ferritin and Sodium levels. Our findings suggest that MMPs play a pivotal role in the pathogenesis of MIS-C and COVID-19 in children and may help distinguish MIS-C from other conditions with overlapping clinical presentation.
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影响因子：
6.7
作者：
Rafferty MS;Burrows H;Joseph JP;Leveille J;Nihtianova S;Amirian ES
通讯作者：
Amirian ES
DOI：
10.1016/s2665-9913(21)00139-9
发表时间：
2021-08
期刊：
The Lancet. Rheumatology
影响因子：
--
作者：
Rodriguez-Smith JJ;Verweyen EL;Clay GM;Esteban YM;de Loizaga SR;Baker EJ;Do T;Dhakal S;Lang SM;Grom AA;Grier D;Schulert GS
通讯作者：
Schulert GS
DOI：
10.1007/s42399-020-00650-0
发表时间：
2021
期刊：
SN comprehensive clinical medicine
影响因子：
--
作者：
Malviya A;Mishra A
通讯作者：
Mishra A
影响因子：
4.2
作者：
Kumar NP;Venkataraman A;Hanna LE;Putlibai S;Karthick M;Rajamanikam A;Sadasivam K;Sundaram B;Babu S
通讯作者：
Babu S
影响因子：
5.6
作者：
Cabral-Pacheco GA;Garza-Veloz I;Castruita-De la Rosa C;Ramirez-Acuña JM;Perez-Romero BA;Guerrero-Rodriguez JF;Martinez-Avila N;Martinez-Fierro ML
通讯作者：
Martinez-Fierro ML