Evidence that the 'active centre' of the herpes simplex virus thymidine kinase involves an interaction between three distinct regions of the polypeptide.
Evidence that the 'active centre' of the herpes simplex virus thymidine kinase involves an interaction between three distinct regions of the polypeptide.
复制标题
有证据表明，单纯疱疹病毒胸苷激酶的“活性中心”涉及多肽的三个不同区域之间的相互作用。
DOI：
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发表时间：
1986
影响因子：
3.8
通讯作者：
M. Inglis
中科院分区：
文献类型：
--
作者：
D. Graham;B. Larder;M. Inglis
1 型单纯疱疹病毒三种突变株和亲本株 SC16 的胸苷激酶基因编码区的核苷酸序列已被确定。已知突变体表达具有不同底物结合特性的胸苷激酶。考虑导致这些生化特性改变的基因损伤。考虑到导致这些生化特性改变的基因损伤，我们推测了酶活性中心的初步模型，涉及多肽三个不同区域的合作。
The nucleotide sequence of the coding region of the thymidine kinase gene from each of three mutant strains of herpes simplex virus type 1 and from the parental strain, SC16, has been determined. The mutants were known to express thymidine kinase enzymes with distinct substrate binding properties. Consideration of the lesions in the genes responsible for these altered biochemical properties. Consideration of the lesions in the genes responsible for these altered biochemical properties has led us to postulate a preliminary model for the active centre of the enzyme, involving the cooperation of three distinct regions of the polypeptide.
狨猴疱疹病毒胸苷激酶基因的核苷酸序列和胸苷激酶多肽的预测氨基酸序列。
影响因子：
3.7
作者：
Otsuka,H;Kit,S
通讯作者：
Kit,S
1型单纯疱疹病毒胸苷激酶基因的核苷酸序列。
DOI：
10.1073/pnas.78.3.1441
发表时间：
1981
影响因子：
11.1
作者：
Wagner,MJ;Sharp,JA;Summers,WC
通讯作者：
Summers,WC