Teneurin trans-axonal signaling prunes topographically missorted axons.
Teneurin trans-axonal signaling prunes topographically missorted axons.
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DOI：
10.1016/j.celrep.2023.112192
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发表时间：
2023-03-28
期刊：
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
构建精确的神经回路需要消除发育过程中不准确形成的轴突投射。尽管轴突修剪是一个选择性过程，但其在体内如何启动和控制仍不清楚。在这里，我们发现细胞表面分子 Glypican-3、Teneurin-3 和 Latrophilin-3 介导的跨轴突信号传导会导致视觉系统中的视网膜轴突错误路由。视网膜专题神经元移植表明，首先沿着视束伸长的先驱腹侧轴突指导修剪该区域错配的背侧轴突。 Glypican-3 和 Teneurin-3 均由腹侧视网膜神经节细胞选择性表达，并协同纠正错误分类的背侧轴突。粘附 G 蛋白偶联受体 Latrophilin-3 沿着背侧轴突发出信号，启动消除拓扑分类错误。总而言之，我们的研究结果显示了 Glypican-3、Teneurin-3 和 Latrophilin-3 在地形束组织中的重要功能，并证明轴突修剪可以通过轴突本身之间的信号传导来启动。构建精确的神经回路需要消除发育过程中不准确形成的轴突投射。斯佩德等人。报道称，由 Glypican-3、Teneurin-3 和 Latrophilin-3.1 介导的跨轴突信号消除了视觉系统中拓扑错误的轴突。因此，轴突可以指导其他轴突的修剪，以实现精确的电路布线。
Building precise neural circuits necessitates the elimination of axonal projections that have inaccurately formed during development. Although axonal pruning is a selective process, how it is initiated and controlled in vivo remains unclear. Here, we show that trans-axonal signaling mediated by the cell surface molecules Glypican-3, Teneurin-3, and Latrophilin-3 prunes misrouted retinal axons in the visual system. Retinotopic neuron transplantations revealed that pioneer ventral axons that elongate first along the optic tract instruct the pruning of dorsal axons that missort in that region. Glypican-3 and Teneurin-3 are both selectively expressed by ventral retinal ganglion cells and cooperate for correcting missorted dorsal axons. The adhesion G-protein-coupled receptor Latrophilin-3 signals along dorsal axons to initiate the elimination of topographic sorting errors. Altogether, our findings show an essential function for Glypican-3, Teneurin-3, and Latrophilin-3 in topographic tract organization and demonstrate that axonal pruning can be initiated by signaling among axons themselves. Building accurate neural circuits requires eliminating axonal projections that have inaccurately formed during development. Spead et al. report that trans-axonal signaling mediated by Glypican-3, Teneurin-3, and Latrophilin-3.1 eliminates the axons that topographically misroute in the visual system. Thus, axons can instruct the pruning of other axons for precise circuit wiring.
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DOI：
10.1016/j.cub.2016.05.035
发表时间：
2016-07-25
期刊：
Current biology : CB
影响因子：
--
作者：
Antinucci P;Suleyman O;Monfries C;Hindges R
通讯作者：
Hindges R
影响因子：
3.7
作者：
Dharmaratne N;Glendining KA;Young TR;Tran H;Sawatari A;Leamey CA
通讯作者：
Leamey CA
影响因子：
64.5
作者：
Akkermans, Onno;Delloye-Bourgeois, Celine;Peregrina, Claudia;Carrasquero-Ordaz, Maria;Kokolaki, Maria;Berbeira-Santana, Miguel;Chavent, Matthieu;Reynaud, Florie;Raj, Ritu;Agirre, Jon;Aksu, Metin;White, Eleanor S.;Lowe, Edward;Ben Amar, Dounia;Zaballa, Sofia;Huo, Jiandong;Pakos, Irene;McCubbin, Patrick T. N.;Comoletti, Davide;Owens, Raymond J.;Robinson, Carol V.;Castellani, Valerie;del Toro, Daniel;Seiradake, Elena
通讯作者：
Seiradake, Elena
影响因子：
16.2
作者：
Hindges, R;McLaughlin, T;O'Leary, DDM
通讯作者：
O'Leary, DDM
影响因子：
2.7
作者：
Ben-Zur, T;Feige, E;Wides, R
通讯作者：
Wides, R