Role of positive selection in functional divergence of mammalian neuronal apoptosis inhibitor proteins during evolution.
Role of positive selection in functional divergence of mammalian neuronal apoptosis inhibitor proteins during evolution.
复制标题
正选择在哺乳动物神经元凋亡抑制蛋白进化过程中功能分化中的作用
DOI：
10.1155/2011/809765
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发表时间：
2011
影响因子：
--
通讯作者：
Xu H
中科院分区：
文献类型：
--
作者：
Kong F;Su Z;Zhou C;Sun C;Liu Y;Zheng D;Yuan H;Yin J;Fang J;Wang S;Xu H
神经元凋亡抑制蛋白（NAIP）是Nod样受体（NLR）蛋白家族的成员。最近的研究表明，一些NAIP基因与人类的先天免疫和许多炎症性疾病密切相关。然而，在其他哺乳动物中没有类似的现象。此外，一些NAIP基因在一些高等哺乳动物的进化过程中经历了假基因化或丢失。因此，我们的目标是确定是否发生了功能分歧，以及自然选择是否在这些基因的进化中发挥了重要作用。结果表明，NAIP基因在正选择的驱动下发生了假基因化和功能分化。正选择也影响了NAIP蛋白的结构，导致进一步的功能分歧。
Neuronal apoptosis inhibitor proteins (NAIPs) are members of Nod-like receptor (NLR) protein family. Recent research demostrated that some NAIP genes were strongly associated with both innate immunity and many inflammatory diseases in humans. However, no similar phenomena have been reported in other mammals. Furthermore, some NAIP genes have undergone pseudogenization or have been lost during the evolution of some higher mammals. We therefore aimed to determine if functional divergence had occurred, and if natural selection had played an important role in the evolution of these genes. The results showed that NAIP genes have undergone pseudogenization and functional divergence, driven by positive selection. Positive selection has also influenced NAIP protein structure, resulting in further functional divergence.
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