The effect of pre- vs. post-reward attainment on EEG asymmetry in melancholic depression.
The effect of pre- vs. post-reward attainment on EEG asymmetry in melancholic depression.
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DOI：
10.1016/j.ijpsycho.2010.11.004
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发表时间：
2011-02
影响因子：
3
通讯作者：
Klein, Daniel N.
中科院分区：
文献类型：
--
作者：
Shankman, Stewart A.;Sarapas, Casey;Klein, Daniel N.
长期以来，临床研究人员一直在理论上探讨奖励处理和积极情感在抑郁症中的作用。一种理论认为，与非酒精性抑郁症患者相比，酒精性抑郁症患者的消费体验更少（即，奖励后），但低预期（奖励前），积极的影响。我们测试了额叶EEG不对称性，预期奖励系统的一个假定标记，是否只存在于个体接受奖励之前或之后（即，在完善奖励处理期间）。我们还研究了是否与脑电异常不对称的α b和功率相关的抑郁症，一种以完善性奖励处理缺陷为特征的疾病。还探索了其他频带（δ、θ或β）的影响。脑电图记录在34个控制，48 nonmalcolic抑郁症，和17 malcolic抑郁症在老虎机任务，旨在引起预期和完善的奖励处理。结果表明，对于阿尔法，额叶脑电不对称性更大的相对左活动是特定的预期奖励处理。在完成阶段，个人与抑郁症表现出不同的后脑电图不对称性比个人与非抑郁症和控制的趋势水平。这第二个发现主要是由于代谢组表现出相对较低的右后活动和非代谢组表现出相对较低的左活动。这些结果表明，后不对称可能是抑郁症和异常的完善奖励加工的一个标志。
Clinical investigators have long theorized about the role of reward processing and positive affect in depression. One theory posits that compared to nonmelancholic depressives, melancholic depressives experience less consummatory (i.e., post-reward), but comparably low anticipatory (prior to reward), positive affect. We tested whether frontal EEG asymmetry, a putative marker of the anticipatory reward system, is present only before an individual receives a reward or also after receiving a reward (i.e., during consummatory reward processing). We also examined whether melancholic depression, a condition characterized by a deficit in consummatory reward processing, is associated with abnormal EEG asymmetries in alphab and power. Effects in other frequency bands (delta, theta, or beta) were also explored. EEG was recorded in 34 controls, 48 nonmelancholic depressives, and 17 melancholic depressives during a slot machine task designed to elicit anticipatory and consummatory reward processing. Results indicated that, for alpha, the frontal EEG asymmetry of greater relative left activity was specific to anticipatory reward processing. During the consummatory phase, individuals with melancholic depression exhibited different posterior EEG asymmetries than individuals with nonmelancholic depression and controls at a trend level. This second finding was largely due to melancholics exhibiting relatively lower right posterior activity and nonmelancholics exhibiting relatively lower left activity. These results suggest that a posterior asymmetry may be a marker for melancholic depression and aberrant consummatory reward processing.
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DOI：
10.1177/1534582305276837
发表时间：
2005-03-01
期刊：
Behavioral and cognitive neuroscience reviews
影响因子：
--
作者：
Demaree, Heath A;Everhart, D Erik;Harrison, David W
通讯作者：
Harrison, David W
影响因子：
5.7
作者：
Cavanagh JF;Frank MJ;Klein TJ;Allen JJ
通讯作者：
Allen JJ
影响因子：
3.3
作者：
Gard, David E.;Gard, Marja Germans;John, Oliver P.
通讯作者：
John, Oliver P.
影响因子：
16.2
作者：
Breiter, HC;Aharon, I;Shizgal, P
通讯作者：
Shizgal, P
影响因子：
4.6
作者：
BRUDER, GE;QUITKIN, FM;HARRISON, WM
通讯作者：
HARRISON, WM