Prevalence of Cardiometabolic Disease Risk Factors in People With HIV Initiating Antiretroviral Therapy at a High-Volume HIV Clinic in Kampala, Uganda.
Prevalence of Cardiometabolic Disease Risk Factors in People With HIV Initiating Antiretroviral Therapy at a High-Volume HIV Clinic in Kampala, Uganda.
复制标题
DOI：
10.1093/ofid/ofad241
复制
发表时间：
2023-06
影响因子：
4.2
通讯作者：
中科院分区：
文献类型：
--
作者：
心脏代谢疾病是艾滋病毒相关发病率和死亡率的主要原因，但在高负担国家没有进行常规筛查。我们的目的是评估代谢综合征（MetS）的患病率和危险因素及其组成部分在乌干达成人艾滋病毒感染者（PWH）开始度鲁特韦为基础的抗逆转录病毒治疗（ART）。我们使用2021年1月至10月期间入组接受度鲁特韦（GLUMED）治疗的乌干达HIV患者葡萄糖代谢变化研究的≥18岁PWH的基线社会人口统计学和临床数据进行了一项横断面研究。MetS定义为具有以下≥3项：腹部肥胖、高血压（HTN）、高血糖症、甘油三酯升高和低高密度脂蛋白胆固醇。多元逻辑回归分析用于评估潜在危险因素与代谢综合征及其组分之间的相关性。分析了309例PWH（100% ART初治，59.2%女性，中位年龄31岁，中位CD 4计数318个细胞/mm 3）。代谢综合征的患病率为13.9%。最常见的心脏代谢疾病是血脂异常（93.6%），其次是腹部肥胖（34.0%）、高血糖（18.4%）和HTN（8.1%）。在校正分析中，MetS与年龄>40岁（校正比值比[aOR]，3.33; 95%CI，1.45-7.67）和CD 4计数>200个细胞/mm 3（aOR，3.79; 95%CI，1.23-11.63）相关。HTN与年龄>40岁相关（aOR，2.96; 95%CI，1.32-6.64），血脂异常与城市居住相关（aOR，4.99; 95%CI，1.35-18.53）。心脏代谢危险因素在这个年轻的乌干达PWH队列中很常见，启动了基于度鲁特韦的ART，强调了在乌干达和类似环境中有计划地实施合并症监测和管理的必要性。
Cardiometabolic diseases are a leading cause of HIV-related morbidity and mortality, yet routine screening is not undertaken in high-burden countries. We aimed to assess the prevalence and risk factors of the metabolic syndrome (MetS) and its components in adult Ugandan people with HIV (PWH) initiating dolutegravir-based antiretroviral therapy (ART). We conducted a cross-sectional study using baseline sociodemographic and clinical data of PWH aged ≥18 years enrolled in the Glucose metabolism changes in Ugandan HIV patients on Dolutegravir (GLUMED) study from January to October 2021. MetS was defined as having ≥3 of the following: abdominal obesity, hypertension (HTN), hyperglycemia, elevated triglycerides, and low high-density lipoprotein cholesterol. Multiple logistic regression was used to assess associations between potential risk factors and MetS and its components. Three hundred nine PWH were analyzed (100% ART-naïve, 59.2% female, median age 31 years, and median CD4 count 318 cells/mm3). The prevalence of MetS was 13.9%. The most common cardiometabolic condition was dyslipidemia (93.6%), followed by abdominal obesity (34.0%), hyperglycemia (18.4%), and HTN (8.1%). In adjusted analysis, MetS was associated with age >40 years (adjusted odds ratio [aOR], 3.33; 95% CI, 1.45–7.67) and CD4 count >200 cells/mm3 (aOR, 3.79; 95% CI, 1.23–11.63). HTN was associated with age >40 years (aOR, 2.96; 95% CI, 1.32–6.64), and dyslipidemia was associated with urban residence (aOR, 4.99; 95% CI, 1.35–18.53). Cardiometabolic risk factors were common in this young Ugandan cohort of PWH initiating dolutegravir-based ART, underscoring the need for programmatic implementation of surveillance and management of comorbidities in Uganda and similar settings.
登录
查看更多内容
影响因子：
3.7
作者：
通讯作者：
--
影响因子：
4.6
作者：
Achhra AC;Lyass A;Borowsky L;Bogorodskaya M;Plutzky J;Massaro JM;D'Agostino RB Sr;Triant VA
通讯作者：
Triant VA
影响因子：
--
作者：
Brown, TT;Cole, SR;Dobs, AS
通讯作者：
Dobs, AS
影响因子：
4.6
作者：
Harimenshi, Deo;Niyongabo, Theodore;Preux, Pierre-Marie;Aboyans, Victor;Desormais, Ileana
通讯作者：
Desormais, Ileana
影响因子：
3.7
作者：
Bavinger C;Bendavid E;Niehaus K;Olshen RA;Olkin I;Sundaram V;Wein N;Holodniy M;Hou N;Owens DK;Desai M
通讯作者：
Desai M