Exploring the therapeutic potential of forkhead box O for outfoxing COVID-19.
Exploring the therapeutic potential of forkhead box O for outfoxing COVID-19.
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DOI：
10.1098/rsob.210069
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发表时间：
2021-06
期刊：
影响因子：
5.8
通讯作者：
Nag A
中科院分区：
文献类型：
--
作者：
Cheema PS;Nandi D;Nag A
COVID-19大流行在全球范围内造成了前所未有的社会浩劫。感染者可能会出现轻度至重度症状，近20%的确诊患者会出现严重并发症，包括多器官衰竭。SARS-CoV-2引起的急性呼吸窘迫主要是由于细胞因子风暴加剧和免疫反应失调。叉头框O（FoxO）转录因子通过调节T和B淋巴细胞的存活、凋亡、氧化应激、发育和成熟、炎性细胞因子的分泌等在维持正常细胞生理中发挥重要作用。该方案将集中于恢复氧化还原和炎症稳态沿着受损组织的修复、淋巴细胞效应细胞和记忆细胞的活化。重新利用FoxO激活剂作为缓解SARS-CoV-2感染后炎症爆发的一种手段，在正在进行的大流行中可以证明是非常有价值的，并为丰富我们未来针对任何此类并发症的抗病毒方法库提供了可靠的基础。总之，我们的综述强调了FoxO激活作为COVID-19临床管理的新武器库的可能功效。
The COVID-19 pandemic has wreaked unprecedented societal havoc worldwide. The infected individuals may present mild to severe symptoms, with nearly 20% of the confirmed patients impaired with significant complications, including multi-organ failure. Acute respiratory distress imposed by SARS-CoV-2 largely results from an aggravated cytokine storm and deregulated immune response. The forkhead box O (FoxO) transcription factors are reported to play a significant role in maintaining normal cell physiology by regulating survival, apoptosis, oxidative stress, development and maturation of T and B lymphocytes, secretion of inflammatory cytokines, etc. We propose a potent anti-inflammatory approach based on activation of the FoxO as an attractive strategy against the novel coronavirus. This regime will be focused on restoring redox and inflammatory homeostasis along with repair of the damaged tissue, activation of lymphocyte effector and memory cells. Repurposing FoxO activators as a means to alleviate the inflammatory burst following SARS-CoV-2 infection can prove immensely valuable in the ongoing pandemic and provide a reliable groundwork for enriching our repertoire of antiviral modalities for any such complication in the future. Altogether, our review highlights the possible efficacy of FoxO activation as a novel arsenal for clinical management of COVID-19.
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DOI：
10.1152/ajplung.1994.267.5.l564
发表时间：
1994-11-01
影响因子：
4.9
作者：
BIONDILLO, DE;KONICEK, SA;IWAMOTO, GK
通讯作者：
IWAMOTO, GK
影响因子：
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作者：
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通讯作者：
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影响因子：
5.8
作者：
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通讯作者：
Perego, Paola
影响因子：
64.8
作者：
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通讯作者：
Hoch, Michael
影响因子：
30.5
作者：
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