Prenatal alcohol exposure and mental health at midlife: A preliminary report on two longitudinal cohorts.
Prenatal alcohol exposure and mental health at midlife: A preliminary report on two longitudinal cohorts.
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DOI：
10.1111/acer.14761
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
Collaborative Initiative on Fetal Alcohol Spectrum Disorders
中科院分区：
文献类型：
--
作者：
Coles CD;Grant TM;Kable JA;Stoner SA;Perez A;Collaborative Initiative on Fetal Alcohol Spectrum Disorders
虽然产前酒精暴露（PAE）的影响已被广泛研究，有相对较少的信息暴露的个人之间的成人心理健康功能。目前的研究检查了产前暴露于酒精并在儿童时期被诊断出这种暴露影响的中年人自我报告的心理健康状况，并将其结果与未暴露的人进行了比较。参与者（N=292）是从亚特兰大和西雅图的两个纵向队列中招募的，并被要求完成一份成人健康问卷，调查他们目前的健康和心理健康状况。调查问卷可以亲自或远程完成，包括有关抑郁和焦虑的当前症状以及精神健康障碍诊断的问题。分析比较了未暴露对照组与两个暴露组：1）酒精暴露伴胎儿酒精效应（FAE）但不符合胎儿酒精综合征（FAS）标准，2）酒精影响并符合FAS标准。两个酒精暴露组都报告了更高水平的当前抑郁症状以及更高的抑郁症、焦虑症、双相情感障碍和/或注意力缺陷/多动障碍诊断患病率。精神障碍无差异。PAE还与更大的环境压力因素相关，包括更高水平的不良儿童事件和更低的当前社会经济地位。路径分析表明，PAE与心境障碍间接相关，其影响是由其他环境因素介导的。PAE与成年中期精神健康障碍的发病率增加有关。这些结果似乎是由于多种压力影响个人，使他们的早期暴露脆弱。通过针对产前酒精使用和后期环境压力源的预防工作，以及早期识别PAE及其影响，可以改善临床结局。
Although the effects of prenatal alcohol exposure (PAE) have been studied extensively, there is relatively little information available on adult mental health functioning among exposed individuals. The current study examined self-reported mental health status among midlife individuals who were prenatally exposed to alcohol and diagnosed in childhood with effects of this exposure and compares their outcomes to those of unexposed individuals. Participants (N=292) were recruited from two longitudinal cohorts in Atlanta and Seattle, and asked to complete an Adult Health Questionnaire that surveyed their current health and mental health status. The questionnaire could be completed either in-person or remotely and included questions about current symptoms of depression and anxiety as well as diagnosis of mental health disorders. Analysis compared a Non-Exposed Contrast group to those in two exposure groups: 1) Alcohol Exposed with Fetal Alcohol Effect (FAE) but not meeting criteria for Fetal Alcohol Syndrome (FAS) and 2) Alcohol Affected and meeting criteria for FAS . Both alcohol-exposed groups reported higher levels of current depressive symptoms as well as higher prevalence of diagnosis of depression, anxiety, bipolar disorder and/or attention deficit/ hyperactivity disorder. No differences were noted for psychotic disorders. PAE was also associated with greater environmental stressors including higher levels of adverse childhood events and lower current socioeconomic status. Path analyses suggested that PAE was indirectly related to mood disorders with its effects being mediated by other environmental factors. PAE is associated with increased rates of mental health disorders in middle adulthood. These outcomes appear to result from multiple stressors affecting individuals made vulnerable by their early exposure. Clinical outcomes could be improved by prevention efforts directed at both prenatal alcohol use and later environmental stressors, and by early identification of PAE and its effects.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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