Development of in-airway laser absorption spectroscopy for respiratory based measurements of cardiac output.
Development of in-airway laser absorption spectroscopy for respiratory based measurements of cardiac output.
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DOI：
10.1038/s41598-021-84649-0
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发表时间：
2021-03-04
影响因子：
4.6
通讯作者：
Ritchie GAD
中科院分区：
文献类型：
--
作者：
Smith NMJ;Couper J;Richmond G;Sandhu D;Hancock G;Robbins PA;Ritchie GAD
确定人体心输出量的呼吸方法可靠地植根于质量平衡，因此可能高度准确。为了解决气体分析中存在的局限性，我们开发了一种基于激光吸收光谱的气道内分析仪，每10 ms提供一次分析。估计心输出量的技术需要相对可溶和不可溶的示踪气体，我们分别使用乙炔和甲烷。使用多程池提供足够的测量灵敏度，以使分析直接在主气流中进行，从而避免了侧流气体分析引入的误差。为了评估性能，在六名志愿者中的每一个中连续五天在休息和运动期间测量心输出量。测量结果具有极高的可重复性（变异系数约7%）。这种新的测量技术为进一步开发计算心输出量的算法提供了稳定的基础。
Respiratory approaches to determining cardiac output in humans are securely rooted in mass balance and therefore potentially highly accurate. To address existing limitations in the gas analysis, we developed an in-airway analyser based on laser absorption spectroscopy to provide analyses every 10 ms. The technique for estimating cardiac output requires both a relatively soluble and insoluble tracer gas, and we employed acetylene and methane for these, respectively. A multipass cell was used to provide sufficient measurement sensitivity to enable analysis directly within the main gas stream, thus avoiding errors introduced by sidestream gas analysis. To assess performance, measurements of cardiac output were made during both rest and exercise on five successive days in each of six volunteers. The measurements were extremely repeatable (coefficient of variation ~ 7%). This new measurement technology provides a stable foundation against which the algorithm to calculate cardiac output can be further developed.
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