Hyperbaric oxygen treatment attenuates the pro-inflammatory and immune responses in apolipoprotein E knockout mice.
Hyperbaric oxygen treatment attenuates the pro-inflammatory and immune responses in apolipoprotein E knockout mice.
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DOI：
10.1016/j.clim.2008.05.004
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发表时间：
2008-09
影响因子：
8.6
通讯作者：
Dory, Ladislav
中科院分区：
文献类型：
--
作者：
Kudchodkar, Bhalchandra;Jones, Harlan;Simecka, Jerry;Dory, Ladislav
关键词：
慢性高压氧（HBO）治疗显着减轻了新西兰白兔子的动脉粥样硬化以及与血浆脂质浓度和脂蛋白谱的无关的APOE敲除（KO）小鼠。由于动脉粥样硬化具有许多慢性炎症性疾病的特征，其中细胞介导的和体液免疫反应都参与，因此我们检查了HBO治疗对免疫反应各个方面的影响。现在，我们证明，在APOE KO小鼠中，HBO治疗显着降低了IgG和IgM类中MDALDL抗体的循环水平，以及对OXLDL挑战的延迟超敏反应（DTH）反应。此外，HBO治疗会导致促炎性刺激（LPS）的促炎细胞因子产生的严重衰减，伴随着抗炎细胞因子IL-10的本组成型产生显着增加，与抗原特异性无关，如T细胞的多克隆激活所示。我们的结果表明，HBO治疗导致T和B细胞对OXLDL或炎症刺激的反应减弱。
Chronic hyperbaric oxygen (HBO) therapy significantly attenuates atherosclerosis in New Zealand white rabbits as well as the apoE knockout (KO) mice, independent of plasma lipid concentrations and lipoprotein profiles. Because atherosclerosis has many features of a chronic inflammatory disease, in which both cell-mediated and humoral immune responses participate, we examined the effect of HBO treatment on various aspects of the immune response. We now demonstrate that in ApoE KO mice, HBO treatment significantly reduces the circulating levels of antibodies to MDALDL, both in the IgG and IgM class, as well as the delayed hypersensitivity (DTH) response to oxLDL challenge. Furthermore, HBO treatment results in a profound attenuation in the production of pro-inflammatory cytokines in response to an inflammatory stimulus (LPS), which is accompanied by a marked increase in the constitutive production of the anti-inflammatory cytokine IL-10 by spleen cells, independent of antigen specificity, as indicated by polyclonal activation of T cells. Our results demonstrate that HBO treatment results in the dampening of T and B cell mediated responses to oxLDL or inflammatory stimuli.
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影响因子：
8.6
作者：
Chen, SY;Chen, YC;Sytwu, HK
通讯作者：
Sytwu, HK
影响因子：
4.4
作者：
Jones, HP;Hodge, LM;Simecka, JW
通讯作者：
Simecka, JW
影响因子：
5.3
作者：
Kudchodkar, Bhalchandra J.;Pierce, Anson;Dory, Ladislav
通讯作者：
Dory, Ladislav
影响因子：
2.7
作者：
MacKenzie, DA;Sollinger, HW;Hullett, DA
通讯作者：
Hullett, DA
影响因子：
15.9
作者：
Gupta, S;Pablo, AM;Schindler, C
通讯作者：
Schindler, C