Task Demands Predict a Dynamic Switch in the Content of Awake Hippocampal Replay.
Task Demands Predict a Dynamic Switch in the Content of Awake Hippocampal Replay.
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DOI：
10.1016/j.neuron.2017.09.035
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发表时间：
2017-11-15
期刊：
影响因子：
16.2
通讯作者：
Barry C
中科院分区：
文献类型：
--
作者：
Ólafsdóttir HF;Carpenter F;Barry C
在行为不动和休息期间海马位置细胞序列的重新激活与记忆巩固和导航计划有关。然而，这些功能是否在不同的行为状态下发生暂时分离仍有待研究。在自定进度的空间任务中，清醒的海马体重播要么发生在向奖励位置移动之前，要么就在到达奖励位置之后，优先涉及与当前轨迹一致的细胞。相比之下，在长时间不动的时期，这种偏见并不明显。值得注意的是，以任务为中心的重新激活的发生预测了后续空间决策的准确性。此外，在不动期间，但不是在运动之前或之后的时期，内嗅皮层深层的网格细胞与海马体一致地重放。因此，海马体重新激活会根据任务需求动态地、突然地在操作模式之间切换，似乎从有利于导航计划的状态转变为有利于记忆巩固的状态。位置单元重播内容在任务参与和脱离任务期间有所不同 到达/离开奖励站点之前，重播描绘了与任务相关的位置 在长时间不动期间没有观察到这种偏差 来自深度 MEC 的网格单元与在长时间停留期间的位置单元一致 Ólafsdóttir 等人。研究发现，在到达奖励地点和离开奖励地点之前，但在不动期间，海马体重播会描绘与当前任务需求相关的地点。以任务为中心的重放的发生可以预测决策的准确性。网格单元仅在静止状态下与重放保持一致。
Reactivation of hippocampal place cell sequences during behavioral immobility and rest has been linked with both memory consolidation and navigational planning. Yet it remains to be investigated whether these functions are temporally segregated, occurring during different behavioral states. During a self-paced spatial task, awake hippocampal replay occurring either immediately before movement toward a reward location or just after arrival at a reward location preferentially involved cells consistent with the current trajectory. In contrast, during periods of extended immobility, no such biases were evident. Notably, the occurrence of task-focused reactivations predicted the accuracy of subsequent spatial decisions. Additionally, during immobility, but not periods preceding or succeeding movement, grid cells in deep layers of the entorhinal cortex replayed coherently with the hippocampus. Thus, hippocampal reactivations dynamically and abruptly switch between operational modes in response to task demands, plausibly moving from a state favoring navigational planning to one geared toward memory consolidation. Place cell replay content varies between periods of task engagement and disengagement Upon arrival/before departure from reward sites, replay depicts task-relevant places No such bias was observed during periods of extended immobility Grid cells from deep MEC were coherent with place cells during extended stops Ólafsdóttir et al. found that, upon arrival at and before departure from reward sites, but not during immobility, hippocampal replay depicts places related to current task demands. Occurrence of task-focused replay predicts decision accuracy. Grid cells were only coherent with replay during immobility.
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影响因子：
25
作者：
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作者：
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通讯作者：
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作者：
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通讯作者：
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DOI：
10.1111/j.1460-9568.2012.08015.x
发表时间：
2012-03
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Erdem UM;Hasselmo M
通讯作者：
Hasselmo M