The role of phosphorus in the development and progression of vascular calcification.
The role of phosphorus in the development and progression of vascular calcification.
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DOI：
10.1053/j.ajkd.2011.07.020
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发表时间：
2011-11
期刊：
影响因子：
--
通讯作者：
Chonchol M
中科院分区：
文献类型：
--
作者：
Kendrick J;Chonchol M
血管钙化与慢性肾脏病（CKD）患者的心血管发病率和死亡率显著相关。CKD患者特有的因素，如高磷血症，使这些患者易于发生早期和进行性血管钙化。高磷血症可能参与了许多触发和促进血管钙化的机制，包括：（1）血管平滑肌细胞（VSMC）由收缩型向骨软骨形成型的转变，并通过钠依赖性磷酸盐共转运蛋白使VSMC基质矿化;（2）诱导VSMC凋亡;（3）抑制单核/巨噬细胞向破骨细胞样细胞的分化;（4）成纤维细胞生长因子23水平升高;和（5）klotho表达降低。目前尚不清楚旨在维持磷酸盐稳态的策略是否可以预防或逆转血管钙化。本综述深入讨论了这些机制，探讨了血管钙化促进剂，抑制剂和底物之间的相互作用，影响磷处理导致CKD患者血管钙化。
Vascular calcification is associated with significant cardiovascular morbidity and mortality in patients with chronic kidney disease (CKD). Factors unique to CKD patients, such as hyperphosphatemia, predispose these patients to early and progressive vascular calcification. Hyperphosphatemia appears to be involved in a number of mechanisms that trigger and advance progression of vascular calcification including (1) transition of vascular smooth muscle cells (VSMC) from a contractile to an osteochondrogenic phenotype and mineralization of VSMC matrix through sodium-dependent phosphate cotransporters; (2) induction of apoptosis of VSMC; (3) inhibition of monocyte/macrophage differentiation into osteoclast-like cells; (4) elevation of fibroblast growth factor 23 levels; and (5) decreases in klotho expression. Whether vascular calcification can be prevented or reversed with strategies aimed at maintaining phosphate homeostasis is currently unknown. The current review discusses these mechanisms in-depth, exploring the interplay among vascular calcification promoters, inhibitors and substrate that affect phosphorus handling leading to vascular calcification in individuals with CKD.
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DOI：
10.1056/nejmoa0706130
发表时间：
2008-08-07
期刊：
The New England journal of medicine
影响因子：
--
作者：
Gutiérrez OM;Mannstadt M;Isakova T;Rauh-Hain JA;Tamez H;Shah A;Smith K;Lee H;Thadhani R;Jüppner H;Wolf M
通讯作者：
Wolf M
磷酸盐粘合剂对骨质重塑和冠状动脉钙化的影响--BRiC 研究的结果
影响因子：
--
作者：
Barreto, Daniela Veit;Barreto, Fellype de Carvalho;Fernandes Canziani, Maria Eugenia
通讯作者：
Fernandes Canziani, Maria Eugenia
影响因子：
158.5
作者：
Detrano, Robert;Guerci, Alan D.;Kronmal, Richard A.
通讯作者：
Kronmal, Richard A.
影响因子：
158.5
作者：
Callister, TQ;Raggi, P;Russo, DJ
通讯作者：
Russo, DJ
影响因子：
105.7
作者：
EDMONDS, ME;MORRISON, N;WATKINS, PJ
通讯作者：
WATKINS, PJ