The inflammatory microenvironment and the urinary microbiome in the initiation and progression of bladder cancer.
The inflammatory microenvironment and the urinary microbiome in the initiation and progression of bladder cancer.
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膀胱癌发生和进展中的炎症微环境和泌尿微生物组
DOI：
10.1016/j.gendis.2020.10.002
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发表时间：
2021-11
期刊：
影响因子：
6.8
通讯作者：
Sui X
中科院分区：
文献类型：
--
作者：
Huang X;Pan T;Yan L;Jin T;Zhang R;Chen B;Feng J;Duan T;Xiang Y;Zhang M;Chen X;Yang Z;Zhang W;Ding X;Xie T;Sui X
越来越多的证据表明，慢性炎症可能在包括膀胱癌在内的各种恶性肿瘤中发挥关键作用。这一假设部分源于尿道微环境中观察到的炎症细胞。慢性炎症可通过激活一系列炎症分子和信号来驱动肿瘤转化和膀胱癌的进展。最近，研究表明，微生物组在膀胱癌的发展和进展中也起着重要作用，这可以通过刺激慢性炎症来介导。实际上，尿液微生物组可以在建立可能促进膀胱癌发展和进展的炎症性尿道微环境中发挥作用。换句话说，由尿液微生物组引起的慢性炎症可能会促进膀胱癌的发生和进展。在这里，我们详细而全面地介绍了慢性炎症，微生物组和膀胱癌之间的联系。最后，我们强调，针对尿液微生物组可能有助于制定膀胱癌预防和个性化治疗的策略。
Accumulating evidence suggests that chronic inflammation may play a critical role in various malignancies, including bladder cancer. This hypothesis stems in part from inflammatory cells observed in the urethral microenvironment. Chronic inflammation may drive neoplastic transformation and the progression of bladder cancer by activating a series of inflammatory molecules and signals. Recently, it has been shown that the microbiome also plays an important role in the development and progression of bladder cancer, which can be mediated through the stimulation of chronic inflammation. In effect, the urinary microbiome can play a role in establishing the inflammatory urethral microenvironment that may facilitate the development and progression of bladder cancer. In other words, chronic inflammation caused by the urinary microbiome may promote the initiation and progression of bladder cancer. Here, we provide a detailed and comprehensive account of the link between chronic inflammation, the microbiome and bladder cancer. Finally, we highlight that targeting the urinary microbiome might enable the development of strategies for bladder cancer prevention and personalized treatment.
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影响因子：
8.8
作者：
Seddighzadeh M;Steineck G;Jansson O;Larsson P;Wijkström H;Adolfsson J;Portwood N;Hansson J;Linder S
通讯作者：
Linder S
影响因子：
6.6
作者：
Chang, Sam S.;Boorjian, Stephen A.;McKiernan, James M.
通讯作者：
McKiernan, James M.
DOI：
10.1038/nrurol.2015.292
发表时间：
2016-02
期刊：
Nature reviews. Urology
影响因子：
--
作者：
Alfano M;Canducci F;Nebuloni M;Clementi M;Montorsi F;Salonia A
通讯作者：
Salonia A
影响因子：
5.5
作者：
Brandau, Sven;Trellakis, Sokratis;Lang, Stephan
通讯作者：
Lang, Stephan
影响因子：
3.7
作者：
Boström MM;Irjala H;Mirtti T;Taimen P;Kauko T;Ålgars A;Jalkanen S;Boström PJ
通讯作者：
Boström PJ