Low interleukin-1alpha messenger RNA levels predict decreased overall survival time of patients with urinary bladder carcinoma.
Low interleukin-1alpha messenger RNA levels predict decreased overall survival time of patients with urinary bladder carcinoma.
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DOI：
10.1054/bjoc.2000.1584
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发表时间：
2001-02-02
影响因子：
8.8
通讯作者：
Linder S
中科院分区：
文献类型：
--
作者：
Seddighzadeh M;Steineck G;Jansson O;Larsson P;Wijkström H;Adolfsson J;Portwood N;Hansson J;Linder S
Due to our inability to exactly characterize tumours, many patients with urinary bladder cancer undergo unnecessary surgery or cytostatic therapy. We have here studied the expression of the cytokine interleukin-1α (IL-1α) in 73 human bladder carcinomas in relation to patient survival, and examined possible relationships between IL-1α and urokinase plasminogen activator (uPA) expression. Expression levels of IL-1α and uPA mRNA were determined by RT-PCR using the quantitative TaqMan technique. The levels of IL-1α mRNA expression did not differ significantly between tumours of different grade or stage. Calculation of the overall survival rates showed a decreased overall survival time for patients with low levels of IL-1α mRNA in their tumours (log rank; P = 0.0002, median follow up: 37 months). Low tumoral IL-1α expression predicted decreased survival of patients with poorly differentiated tumours (P< 0.005) and of patients with invasive tumours (P = 0.02). uPA expression was about 4-fold increased in poorly differentiated tumours. High levels of uPA mRNA were associated with decreased overall survival times (log rank; P = 0.032, n = 60). We conclude that IL-1α is important for bladder cancer biology, and that measurements of this cytokine may be useful in pre-treatment characterization of urinary bladder cancer. © 2001 Cancer Research Campaign http://www.bjcancer.com
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影响因子：
8.8
作者：
Linder, C;Byström, P;Linder, S
通讯作者：
Linder, S
影响因子：
7
作者：
Heid, CA;Stevens, J;Williams, PM
通讯作者：
Williams, PM
DOI：
10.1016/0006-291x(87)91060-6
发表时间：
1987-06-15
影响因子：
3.1
作者：
NORIOKA, K;HARA, M;NAKAMURA, H
通讯作者：
NAKAMURA, H
影响因子：
6.6
作者：
LAMM, DL
通讯作者：
LAMM, DL
影响因子：
3.7
作者：
KAPLAN, EL;MEIER, P
通讯作者：
MEIER, P