New Insights on Molecular Mechanism of Hepatitis B Virus Covalently Closed Circular DNA Formation.
New Insights on Molecular Mechanism of Hepatitis B Virus Covalently Closed Circular DNA Formation.
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作者：
Marchetti AL;Guo H
B型肝炎病毒（HBV）的慢性因子，特别是共价闭合环状DNA（cccDNA），是在慢性B型肝炎患者的肝脏中建立的高度稳定和活性的病毒附加体基因组，作为疾病的恒定来源。能够靶向和消除cccDNA是真正治愈HBV的最终目标。然而，HBV cccDNA是如何从病毒基因组松弛环状DNA（rcDNA）形成的，以及由什么宿主因素形成一直是长期存在的研究问题。一般认为，HBV通过DNA修复机制劫持细胞功能，将rcDNA的开放环状DNA构象转变为cccDNA。在HBV研究界的巨大努力下，我们对cccDNA形成的理解最近有了几次飞跃。我们的目的是在这篇综述中分析最近的报告显示的证据，细胞因子参与的cccDNA生物合成的分子途径。
The chronic factor of the Hepatitis B Virus (HBV), specifically the covalently closed circular DNA (cccDNA), is a highly stable and active viral episomal genome established in the livers of chronic hepatitis B patients as a constant source of disease. Being able to target and eliminate cccDNA is the end goal for a genuine cure for HBV. Yet how HBV cccDNA is formed from the viral genomic relaxed circular DNA (rcDNA) and by what host factors had been long-standing research questions. It is generally acknowledged that HBV hijacks cellular functions to turn the open circular DNA conformation of rcDNA into cccDNA through DNA repair mechanisms. With great efforts from the HBV research community, there have been several recent leaps in our understanding of cccDNA formation. It is our goal in this review to analyze the recent reports showing evidence of cellular factor’s involvement in the molecular pathway of cccDNA biosynthesis.
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DOI：
10.1007/978-1-62703-484-5_13
发表时间：
2013
期刊：
Methods in molecular biology (Clifton, N.J.)
影响因子：
--
作者：
Cai, Dawei;Nie, Hui;Yan, Ran;Guo, Ju-Tao;Block, Timothy M;Guo, Haitao
通讯作者：
Guo, Haitao
DOI：
10.3390/v9010021
发表时间：
2017-01-21
期刊：
Viruses
影响因子：
--
作者：
Gallucci L;Kann M
通讯作者：
Kann M
影响因子：
5.4
作者：
GUIDOTTI, LG;MATZKE, B;CHISARI, FV
通讯作者：
CHISARI, FV
SAMHD1促进DNA终端切除术，以通过同源重组促进DNA修复。
影响因子：
8.8
作者：
Daddacha W;Koyen AE;Bastien AJ;Head PE;Dhere VR;Nabeta GN;Connolly EC;Werner E;Madden MZ;Daly MB;Minten EV;Whelan DR;Schlafstein AJ;Zhang H;Anand R;Doronio C;Withers AE;Shepard C;Sundaram RK;Deng X;Dynan WS;Wang Y;Bindra RS;Cejka P;Rothenberg E;Doetsch PW;Kim B;Yu DS
通讯作者：
Yu DS
影响因子：
5.4
作者：
Gao, Weifan;Hu, Jianming
通讯作者：
Hu, Jianming