Hydrogen sulfide regulates insulin secretion and insulin resistance in diabetes mellitus, a new promising target for diabetes mellitus treatment? A review.
Hydrogen sulfide regulates insulin secretion and insulin resistance in diabetes mellitus, a new promising target for diabetes mellitus treatment? A review.
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硫化氢调节糖尿病中的胰岛素分泌和胰岛素抵抗，是糖尿病治疗的新靶标吗？
DOI：
10.1016/j.jare.2020.02.013
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发表时间：
2021-01
影响因子：
10.7
通讯作者：
Jin H
中科院分区：
文献类型：
--
作者：
Zhang H;Huang Y;Chen S;Tang C;Wang G;Du J;Jin H
胰岛素抵抗和胰岛素分泌受损导致葡萄糖代谢紊乱，这有助于糖尿病的发展。硫化氢（H2S）是一种新型的气体递质，在调节糖代谢稳态中起重要作用。本文就硫化氢在胰岛素分泌和胰岛素抵抗调节中的作用及其机制进行综述和讨论。H2S可在胰岛β细胞、肝脏、脂肪、骨骼肌和下丘脑中内源性产生，并调节局部和全身葡萄糖代谢。据报道，H2S抑制胰岛素分泌，促进或减少胰岛β细胞凋亡。它在胰岛素敏感组织中对胰岛素敏感性的调节起重要作用。H2S抑制葡萄糖摄取和糖原储存，并促进或抑制肝脏中的线粒体生物合成、线粒体生物合成和线粒体生物能量学。在脂肪组织中，一些研究者指出H2S促进脂肪细胞中的葡萄糖摄取，而其他研究报告H2S抑制这一过程。H2S还显示出促进脂肪形成、抑制脂解、以及调节脂肪细胞的脂联素和MCP-1分泌。在骨骼肌中，H2S增加葡萄糖摄取并改善胰岛素敏感性。还观察到H2S调节肌肉中的生物钟基因。下丘脑CBS/H2S通路通过脑-脂肪相互作用减轻肥胖并改善胰岛素敏感性。大多数研究表明糖尿病患者血浆H2S水平降低。然而，H2S调节全身葡萄糖代谢的机制仍不清楚。H2S是否是糖尿病治疗的新靶点值得进一步研究。
Insulin resistance and impaired insulin secretion lead to disorders of glucose metabolism, which contributes to the development of diabetes. Hydrogen sulfide (H2S), a novel gasotransmitter, is found to play important roles in regulation of glucose metabolism homeostasis. This study aimed to summarize and discuss current data about the function of H2S in insulin secretion and insulin resistance regulation as well as the underlying mechanisms. H2S could be endogenously produced in islet β cells, liver, adipose, skeletal muscles, and the hypothalamus, and regulates local and systemic glucose metabolism. It is reported that H2S suppresses insulin secretion, promotes or reduces the apoptosis of islet β cells. It plays important roles in the regulation of insulin sensitivity in insulin responsive tissues. H2S inhibits glucose uptake and glycogen storage, and promotes or inhibits gluconeogenesis, mitochondrial biogenesis and mitochondrial bioenergetics in the liver. In adipose tissue, several investigators indicated that H2S promoted glucose uptake in adipocytes, while other studies reported that H2S inhibits this process. H2S has also been shown to promote adipogenesis, inhibit lipolysis, and regulate adiponectin and MCP-1 secretion from adipocytes. In skeletal muscle, H2S increases glucose uptake and improves insulin sensitivity. It is also observed that H2S modulates circadian-clock genes in muscle. Hypothalamic CBS/H2S pathway reduces obesity and improves insulin sensitivity via the brain-adipose interaction. Most studies indicated plasma H2S levels decreased in diabetic patients. However, the mechanisms by which H2S regulates systemic glucose metabolism remain unclear. Whether H2S acts as a new promising target for diabetes mellitus treatment merits further studies.
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