Flow visualization of a pediatric ventricular assist device during stroke volume reductions related to weaning.
Flow visualization of a pediatric ventricular assist device during stroke volume reductions related to weaning.
复制标题
在与断奶有关的中风体积减少过程中，小儿心室辅助装置的流动可视化。
DOI：
10.1007/s10439-011-0291-8
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发表时间：
2011-07
影响因子：
3.8
通讯作者：
Manning, Keefe B.
中科院分区：
文献类型：
--
作者：
Roszelle, Breigh N.;Deutsch, Steven;Weiss, William J.;Manning, Keefe B.
关键词：
本研究的目的是定义脉动气动儿童心室辅助装置 (PVAD) 的流体力学，以应对装置撤机和心肌恢复期间遇到的流速降低，并将结果与血栓栓塞事件的可能性联系起来。我们将 PVAD 的丙烯酸模型放置在充满粘弹性血液模拟物的模拟循环回路中，并在四个每搏输出量 (SV) 下运行，每个输出量有两种不同的填充条件，以模拟设备的流速如何降低。粒子图像测速用于获取流场数据。我们发现，与节拍率降低方法相比，SV 降低方法可提供更好的旋转流动和更高的壁剪切速率；具有压缩舒张时间的快速充盈状态优于缓慢充盈状态；并且，SV 降低至 40% 会导致流体运动和壁剪切率大大降低，从而可能增加装置的血栓形成性。 SV 减少是撤机期间减少流量的可行选择，但是，它确实会导致设备流场发生重大变化，并且需要未来的研究来开发桥接恢复期间 PVAD 的操作协议。
The aim of this study is to define the fluid mechanics of a pulsatile pneumatically driven pediatric ventricular assist device (PVAD), for the reduced flow rates encountered during device weaning and myocardial recovery, and relate the results to the potential for thromboembolic events. We place an acrylic model of the PVAD in a mock circulatory loop filled with a viscoelastic blood analog and operate at four stroke volumes (SVs), each with two different filling conditions, to mimic how the flow rate of the device may be reduced. Particle image velocimetry is used to acquire flow field data. We find that a SV reduction method provides better rotational flow and higher wall shear rates than a beat rate reduction method; that a quick filling condition with a compressed diastolic time is better than a slow filling condition; and, that a reduction in SV to 40% led to greatly reduced fluid movement and wall shear rates that could increase the thrombogenicity of the device. SV reduction is a viable option for flow reduction during weaning, however, it does lead to significant changes to the device flow field and future studies are needed to develop operational protocols for the PVAD during bridge-to-recovery.
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影响因子：
4.6
作者：
Hetzer, Roland;Potapov, Evgenij V.;Hennig, Ewald
通讯作者：
Hennig, Ewald
影响因子：
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作者：
Hochareon, P;Manning, KB;Deutsch, S
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
Manning, Keefe B.;Wivholm, Brandon D.;Deutsch, Steven
通讯作者：
Deutsch, Steven
影响因子：
2.4
作者：
Carney, Elizabeth L.;Clark, J. Brian;Weiss, William J.
通讯作者：
Weiss, William J.