Gastric epithelial dysplasia: characteristics and long-term follow-up results after endoscopic resection according to morphological categorization.
Gastric epithelial dysplasia: characteristics and long-term follow-up results after endoscopic resection according to morphological categorization.
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DOI：
10.1186/s12876-015-0249-7
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发表时间：
2015-02-12
影响因子：
2.4
通讯作者：
Song GA
中科院分区：
文献类型：
--
作者：
Baek DH;Kim GH;Park DY;Lee BE;Jeon HK;Lim W;Song GA
胃上皮异常增生症(GED)在形态上可分为腺瘤型和小凹病变型。到目前为止，根据GEDs的形态类型对GEDs的临床特征的研究很少。因此，我们根据GED的形态特征，探讨GED患者的临床病理特点及经胃镜下切除后的远期随访结果。共有357名在2008年1月至2009年12月期间在釜山国立大学医院接受内窥镜下GEDs切除的患者纳入该研究。根据组织学检查，GED在形态上可分为腺瘤型、凹陷型和混合型。分析GEDs患者的临床病理特点和内窥镜下切除的结果。本组病例分为3组：腺瘤型(n = 16 7，46.8%)、凹陷型(n = 10 3，2 8.9%)和混合型(n = 87，2 4.3%)。与腺瘤型相比，凹陷型病变多位于胃窦/幽门，病变平坦/凹陷，颜色正常/淡红，高级别异型增生发生率较高。随访期(中位数37.3个月)，同步和异时病变的总发生率分别为20.8%和20.1%，其中同步和异时胃癌的发生率分别为8.7%和5.4%。在不同的病理类型中，同时性和异时性病变的发生率没有显著差异。GEDs的临床病理特征因形态类型不同而不同。无论形态如何，在胃镜下切除GEDs后，通常会发现同步和异时性胃癌。因此，所有患者都应该在内窥镜下切除GEDs后进行密切的随访监测。
Gastric epithelial dysplasia (GED) can be morphologically categorized into adenomatous and foveolar types. To date, there have been few studies on the clinical characteristics of GEDs according to the morphologic types. Therefore, we here aimed to elucidate the clinicopathologic characteristics of patients with GED and the long-term follow-up results after endoscopic resection according to the morphologic characteristics of GEDs. A total of 357 patients who underwent endoscopic resection for GEDs at Pusan National University Hospital between January 2008 and December 2009 were included in the study. GEDs were morphologically categorized into adenomatous, foveolar, and hybrid types on histologic examination. The clinicopathologic characteristics of patients with GEDs and outcomes of endoscopic resection were analyzed. Patients with GED were divided into 3 groups: adenomatous (n = 167, 46.8%), foveolar (n = 103, 28.9%), and hybrid (n = 87, 24.3%) types. Compared to the adenomatous type, foveolar type lesions were more frequently located in the antrum/pylorus, flat/depressed lesions, and normal/reddish in color; and showed more frequent high-grade dysplasia. During the follow–up period (median, 37.3 months), the overall incidence of synchronous and metachronous lesions was 20.8% and 20.1%, respectively; of these, the incidence of synchronous and metachronous gastric cancer was 8.7% and 5.4%, respectively. There were no significant differences in the incidence of synchronous and metachronous lesions according to morphologic types. GEDs appear to have different clinicopathologic characteristics according to morphologic types. Irrespective of the morphology, synchronous and metachronous gastric cancers are commonly found after endoscopic resection of GEDs. Therefore, close follow-up surveillance after endoscopic resection of GEDs should be performed for all patients.
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影响因子：
3.4
作者：
MORSON, BC;SOBIN, LH;SERCKHANSSEN, A
通讯作者：
SERCKHANSSEN, A
影响因子：
9.3
作者：
FARINATI, F;RUGGE, M;BAFFA, R
通讯作者：
BAFFA, R
DOI：
10.1046/j.1440-1746.2001.02568.x
发表时间：
2001-09-01
影响因子：
4.1
作者：
Kim, JH;Kim, HY;Choi, KW
通讯作者：
Choi, KW
DOI：
10.1097/meg.0b013e328318ed42
发表时间：
2009-08-01
影响因子：
2.1
作者：
Nam, Su Youn;Choi, Il Ju;Kim, Young-Woo
通讯作者：
Kim, Young-Woo
影响因子：
9.3
作者：
Dinis-Ribeiro, M.;Areia, M.;Kuipers, E. J.
通讯作者：
Kuipers, E. J.