Biogenesis and regulatory hierarchy of phased small interfering RNAs in plants.
Biogenesis and regulatory hierarchy of phased small interfering RNAs in plants.
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植物中阶段性小干扰RNA的生物发生和调控层次
DOI：
10.1111/pbi.12882
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发表时间：
2018-05
影响因子：
13.8
通讯作者：
Wu L
中科院分区：
文献类型：
--
作者：
Deng P;Muhammad S;Cao M;Wu L
植物中产生了几种小RNA，包括microRNA（miRNAs）和小干扰RNA（siRNAs），以调节发育、基因组稳定性和对不利环境的响应。Phased siRNA（phasiRNA）是一种二级siRNA，由miRNA介导的RNA转录物切割加工而成，可提高沉默效率或同时抑制多个靶基因。反式作用siRNA（ta-siRNA）是一类特殊的phasiRNA，由非编码转录本产生，使靶点反式沉默。最初认为“一击”和“两击”模型对于处理不同的TAS前体是必不可少的;然而，最近显示单次击中事件足以触发所有类型的ta-siRNA。本文就植物ta-siRNAs的生物起源、靶向模式和调控网络等方面的研究进展进行综述。我们还总结了其他phasiRNA的产生及其对植物可能的生物学益处的最新进展。
Summary Several varieties of small RNAs including microRNAs (miRNAs) and small interfering RNAs (siRNAs) are generated in plants to regulate development, genome stability and response to adverse environments. Phased siRNA (phasiRNA) is a type of secondary siRNA that is processed from a miRNA‐mediated cleavage of RNA transcripts, increasing silencing efficiency or simultaneously suppressing multiple target genes. Trans‐acting siRNAs (ta‐siRNAs) are a particular class of phasiRNA produced from noncoding transcripts that silence targets in trans. It was originally thought that ‘one‐hit’ and ‘two‐hit’ models were essential for processing distinct TAS precursors; however, a single hit event was recently shown to be sufficient at triggering all types of ta‐siRNAs. This review discusses the findings about biogenesis, targeting modes and regulatory networks of plant ta‐siRNAs. We also summarize recent advances in the generation of other phasiRNAs and their possible biological benefits to plants.
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作者：
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通讯作者：
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DOI：
10.1073/pnas.0611119104
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