Characteristics and immune checkpoint status of radioiodine-refractory recurrent papillary thyroid carcinomas from Ukrainian Chornobyl Tissue Bank donors.
Characteristics and immune checkpoint status of radioiodine-refractory recurrent papillary thyroid carcinomas from Ukrainian Chornobyl Tissue Bank donors.
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DOI：
10.3389/fendo.2023.1343848
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发表时间：
2023
影响因子：
5.2
通讯作者：
中科院分区：
文献类型：
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作者：
放射性碘难治性（RAI-R）复发性甲状腺乳头状癌（PTC）在老年患者中更常见，预后不良。在有或无儿童期辐射暴露史的年轻和中年患者中，关于RAI-R复发性PTC的患病率和特征的数据描述不足。本研究的目的是：i）确定在绒毛膜组织库（CTB）的供体中RAI-R复发性PTC的频率，并分析原发性肿瘤（PT）、原发性转移瘤（PMTS）、复发性转移瘤（RMTS）的临床病理学特征和RMTS的风险因素，和ii）确定RAI-R复发性PTC的免疫检查点状态（ICS）并评估与ICS阳性相关的因素。确定了60例RAI-R复发性PTC（46例暴露于辐射，14例未暴露，占CTB登记的所有病例的2.5%），来自年龄最大为48岁的乌克兰患者。PT的临床病理特征与来自同一患者的PMTS和RMTS的临床病理特征中度至弱相似，而转移组织高度相似。RMTS的多变量模型包括PT的主要固体-小梁生长模式、囊性变化、N1 b转移和辐射导致PTC的可能性（POC）作为风险因素。在这些因素中，外侧PMTS（N1 b）的影响最大。较长的潜伏期（POC成分）是第二个统计学显著特征。PT和RAI-R RMTS之间的ICS一致性百分比为91.5%; 23.7%的PT和28.8%的RMTS具有阳性ICS（阳性PD-L1肿瘤上皮细胞（TEC）和阳性PD-L1/PD 1肿瘤相关免疫细胞）。PT的ICS阳性与PT浸润区明显的嗜酸细胞改变和高密度的p16 INK 4A阳性TEC相关。在RMTS中，ICS阳性与PT的显著嗜酸细胞改变和Ki-67标记指数≥ 4.5%相关，RMTS的主要固体-小梁生长模式、Ki-67标记指数≥ 7.6%和p16 INK 4A阳性相关。这些发现具有临床意义，可能有助于为可能涉及免疫治疗的RAI-R复发性PTC患者制定个体化治疗方法。
The radioiodine-refractory (RAI-R) recurrent papillary thyroid carcinomas (PTCs) are more frequent in elderly patients and have an unfavorable prognosis. Data on the prevalence and characteristics of RAI-R recurrent PTCs in patients of young and middle age with or without a history of radiation exposure in childhood are poorly described. The aim of the current study was: i) to determine the frequency of RAI-R recurrent PTCs among donors of the Chornobyl Tissue Bank (CTB) and analyze the clinicopathological features of primary tumors (PTs), primary metastases (PMTSs), recurrent metastases (RMTSs) and risk factors for RMTS, and ii) to determine the immune checkpoint status (ICS) of the RAI-R recurrent PTCs and to assess the factors associated with ICS positivity. Sixty RAI-R recurrent PTCs (46 exposed to radiation and 14 non-exposed, 2.5% of all cases registered with the CTB) from the Ukrainian patients aged up to 48 years were identified. The clinicopathological characteristics of the PTs moderately to weakly resembled those of the PMTS and RMTS from the same patients while the metastatic tissues were highly similar. The multivariate model of RMTS included the dominant solid-trabecular growth pattern of the PT, cystic changes, N1b metastases, and the probability of a causation (POC) of PTC by radiation as risk factors. Among these factors, the lateral PMTS (N1b) had the strongest effect. The longer period of latency (a POC component) was the second statistically significant characteristic. ICS percent agreement between the PT and RAI-R RMTS was 91.5%; 23.7% of PTs and 28.8% of RMTSs had positive ICS (positive PD-L1 tumor epithelial cells (TECs) and positive PD-L1/PD1 tumor-associated immune cells). ICS positivity of PTs was associated with pronounced oncocytic changes and high density of the p16INK4A-positive TECs in the invasive areas of PTs. In RMTSs, ICS positivity was associated with pronounced oncocytic changes and Ki-67 labeling index ≥ 4.5% of PTs, and the dominant solid-trabecular growth pattern, Ki-67 labeling index ≥ 7.6% and p16INK4A-positivity of RMTS. The findings are of clinical relevance and may be useful for developing individual treatment approaches for patients with RAI-R recurrent PTCs possibly involving immunotherapy.
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影响因子：
16.6
作者：
Kim YH;Choi YW;Lee J;Soh EY;Kim JH;Park TJ
通讯作者：
Park TJ
影响因子：
5.8
作者：
Durante, C.;Haddy, N.;Schlumberger, M.
通讯作者：
Schlumberger, M.
影响因子：
10.6
作者：
Nakanishi, Kenichi;Kikumori, Toyone;Kodera, Yasuhiro
通讯作者：
Kodera, Yasuhiro
影响因子：
5.2
作者：
Zurnadzhy L;Bogdanova T;Rogounovitch TI;Ito M;Tronko M;Yamashita S;Mitsutake N;Chernyshov S;Masiuk S;Saenko VA
通讯作者：
Saenko VA
DOI：
10.7759/cureus.17488
发表时间：
2021-08
期刊：
Cureus
影响因子：
--
作者：
Jafri S;Yaqub A
通讯作者：
Yaqub A