The Osteoclast in Bone Metastasis: Player and Target.
The Osteoclast in Bone Metastasis: Player and Target.
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DOI：
10.3390/cancers10070218
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发表时间：
2018-06-27
期刊：
影响因子：
5.2
通讯作者：
Rucci N
中科院分区：
文献类型：
--
作者：
Maurizi A;Rucci N
骨转移通常是乳腺癌和前列腺癌患者的最终命运。根据转移作为不治之症的定义，迄今为止，对于肿瘤相关的骨转移没有有效的治疗方法，这对该领域的研究人员来说是真实的挑战。骨是一个异质环境，代表了肿瘤细胞的肥沃土壤，支持它们的生长。在骨中存在的不同细胞类型中，在这篇综述中，我们将把注意力集中在破骨细胞上，破骨细胞是所谓的“恶性循环”中的关键角色，这种现象由肿瘤细胞引发，最终导致肿瘤增殖以及骨失调，从而促进骨转移的发展。通过激活破骨细胞将肿瘤细胞连接到骨的复杂网络代表了治疗骨转移的富有成效的靶点。在这篇综述中，我们将描述肿瘤细胞如何通过积极影响破骨细胞的形成和活性来扰乱骨微环境。此外，我们将描述目前用于治疗骨转移的抗吸收药物以及能够影响癌细胞和破骨细胞的新的靶向治疗。
Bone metastases are frequently the final fate of breast and prostate cancer patients. According to the definition of metastasis as an incurable disease, to date there are no effective treatments for tumor-associated bone metastases and this represents a real challenge for the researchers in the field. The bone is a heterogeneous environment that represents a fertile soil for tumor cells, supporting their growth. Among the different cell types present in the bone, in this review we will focus our attention on the osteoclasts, which are crucial players in the so called “vicious cycle”, a phenomenon triggered by tumor cells eventually leading to both tumor proliferation as well as bone deregulation, thus fueling the development of bone metastasis. The complex network, linking tumor cells to the bone by activating osteoclasts, represents a fruitful target for the treatment of bone metastases. In this review we will describe how tumor cells perturb the bone microenvironment by actively influencing osteoclast formation and activity. Moreover, we will describe the current antiresorptive drugs employed in the treatment of bone metastases as well as new, targeted therapies able to affect both cancer cells and osteoclasts.
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影响因子：
15.3
作者：
Asagiri, M;Sato, K;Takayanagi, H
通讯作者：
Takayanagi, H
DOI：
10.1083/jcb.102.4.1164
发表时间：
1986-04
期刊：
The Journal of cell biology
影响因子：
--
作者：
Blair HC;Kahn AJ;Crouch EC;Jeffrey JJ;Teitelbaum SL
通讯作者：
Teitelbaum SL
影响因子：
6.2
作者：
Clohisy, DR;Mantyh, PW
通讯作者：
Mantyh, PW
影响因子：
11.8
作者：
Coleman, RE
通讯作者：
Coleman, RE
影响因子：
10.5
作者：
Dougall, WC;Glaccum, M;Schuh, J
通讯作者：
Schuh, J